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Evaluation of Inflammation Caused by Cardiopulmonary Bypass in a Small Animal Model

Department of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Niigata 950-3198, Japan
Biology 2020, 9(4), 81; https://doi.org/10.3390/biology9040081
Received: 17 March 2020 / Revised: 16 April 2020 / Accepted: 17 April 2020 / Published: 20 April 2020
(This article belongs to the Section Medical Biology)
Extracorporeal circulation (ECC) methods are being increasingly used for mechanical support of respiratory and cardio-circulatory failure. Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patient’s life by providing an appropriate blood flow and oxygen supply to principal organs. On the other hand, systemic inflammatory responses in patients undergoing cardiovascular surgery supported by CPB contribute significantly to CPB-associated mortality and morbidity. Our previous research showed that CPB causes a systemic inflammatory response and organ damage in a small animal CPB model. We have been studying the effects of hyperoxia and blood plasma substitute on CPB. In this review, we present a study focusing on the systemic inflammatory response during CPB, along with our findings. View Full-Text
Keywords: systemic inflammation; cytokine; oxidative stress extracorporeal circulation; cardiopulmonary bypass systemic inflammation; cytokine; oxidative stress extracorporeal circulation; cardiopulmonary bypass
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Fujii, Y. Evaluation of Inflammation Caused by Cardiopulmonary Bypass in a Small Animal Model. Biology 2020, 9, 81.

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