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Contribution of Neurotrophins to the Immune System Regulation and Possible Connection to Alcohol Addiction

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Laboratory of Clinical Microbiology and Biotechnology of Bacteriophages G.N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia
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Federal Scientific Clinical Center for Resuscitation and Rehabilitation, 109240 Moscow, Russia
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I. M. Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia
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Department of Internal Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei 100, Taiwan
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Laboratory of Infection Pathology and Molecular Microecology, Institute of Human Morphology, 117418 Moscow, Russia
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Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia
*
Author to whom correspondence should be addressed.
Biology 2020, 9(4), 63; https://doi.org/10.3390/biology9040063
Received: 21 February 2020 / Revised: 18 March 2020 / Accepted: 19 March 2020 / Published: 28 March 2020
(This article belongs to the Section Cell Biology)
The first references to neurotrophic factors date back to the middle of the 20th century when the nerve growth factor (NGF) was first discovered. Later studies delivered a large amount of data on neurotrophic factors. However, many questions regarding neurotrophin signaling still remain unanswered. One of the principal topics in neurotrophin research is their role in the immune system regulation. Another important research question is the possible involvement of neurotrophin signaling in the pathological processes associated with alcoholism. Among known neurotrophins, NT-4 remains the least studied and appears to be involved in alcoholism and chronic stress pathogenesis. In this review we discuss known neurotrophin signaling cascades mediated by different neurotrophin receptors, as well as provide a generalization of the data regarding the influence of neurotrophins NGF, BDNF, and NT-4 on the immune system and their potential contribution to the pathogenesis of alcoholism. View Full-Text
Keywords: neurotrophin; alcohol addiction; NGF; BDNF; inflammation neurotrophin; alcohol addiction; NGF; BDNF; inflammation
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Kozlov, E.M.; Grechko, A.V.; Chegodaev, Y.S.; Wu, W.-K.; Orekhov, A.N. Contribution of Neurotrophins to the Immune System Regulation and Possible Connection to Alcohol Addiction. Biology 2020, 9, 63.

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