MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis
Abstract
:Simple Summary
Abstract
1. Introduction
2. MOB Proteins in Multicellular Eukaryotes
2.1. Functions of MOB Proteins
2.1.1. Tissue Homeostasis: MOB as Regulators of Cell Proliferation and Apoptosis
2.1.2. Morphogenesis: A MOB Function in Various Species and Cell Types
2.1.3. Cell Cycle Progression: MOBs as Regulators of Mitosis, Cytokinesis, and Centrosome Biology
2.1.4. Differentiation and Stem Cell Maintenance: MOB in a Crossroad between Morphogenesis, Tissue Homeostasis, and Cell Cycle Regulation
2.2. Regulation of MOB Proteins
2.2.1. Post-Translation Modifications of MOBs
2.2.2. Transcriptional and Post-Transcriptional Regulation of MOBs
3. MOB Proteins in Unicellular Organisms: The Roots of Multicellularity?
3.1. MOB Proteins in Yeast: From Cell Division to Signaling Pathways
3.2. MOB Proteins in the Alveolate: From Cytokinesis to Morphology
3.2.1. MOB in Ciliates
3.2.2. MOB in Apicomplexa
3.3. Non-Alveolate Protozoa
3.4. MOBs: From Unicellular to Multicellular Organisms
4. Concluding Remarks
4.1. The Ancient MOB: In the Crossroad of Accurate Cell Division, Cytokinesis, and Morphogenesis
4.2. MOB: New Roles, the Same Function?
Author Contributions
Funding
Conflicts of Interest
References
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Protein | Described Functions | Functional Category | References | ||||
---|---|---|---|---|---|---|---|
TH | M | D | CC | ||||
Mammals and birds | HsMOB1 | Tissue growth (suppressor); apoptotic signaling; mitotic exit; protein complex positioning to spindle midzone, mitotic spindle orientation; centrosome duplication and disjunction; cytokinesis | X | X | [13,14,27,28,29,30,34,48,55,56,57] | ||
HsMOB2 | Tissue growth (suppressor); cortical development; mitotic spindle orientation; centrosome duplication; DNA damage response | X | X | X | [14,33,48,54,58,59,60,61] | ||
HsMOB3 | Tissue growth (enhancer through MST1 inhibition); apoptotic signaling | X | X | [14,36] | |||
HsMOB4 | Tissue growth (enhancer through MST1-MOB1 complex inhibition) | X | [34,35] | ||||
MmMOB1 | Tissue growth (suppressor); lung and neuronal morphogenesis; stem cell differentiation and maintenance; centrosome duplication; actin cytoskeleton polarization | X | X | X | X | [10,37,38,39,40,53,62,63] | |
MmMOB2 | Neuronal and cortical development; actin cytoskeleton organization. | X | [59,64] | ||||
MmMOB4 | Dendritic arborization in neuronal development | X | [34] | ||||
CfMOB1 | Photoreceptor growth; mitosis | X | X | [41] | |||
GgMOB2 | Tissue growth (suppressor); follicle development | X | X | [42] | |||
Insects | DmMOB1 | Tissue growth (suppressor); stem cell differentiation; chromosome segregation | X | X | X | [2,15,26,62,65] | |
DmMOB2 | Wing hair, photoreceptor and neuromuscular junction morphogenesis | X | [66,67,68] | ||||
DmMOB4 | Synapse morphogenesis and microtubule organization; spindle pole assembly; axonal transport of autophagosomes | X | X | [69,70,71] | |||
Plants | AtMOB1 | Plant growth (enhancer); development of stem and root; sporogenesis and gametogenesis; stem cell differentiation and maintenance; apoptotic signaling; cytokinesis | X | X | X | X | [43,44,45,46] |
MsMOB1 | Tissue growth (suppressor); stem cell association | X | X | [47,72] | |||
Fungi | NcMOB1 | Tissue growth (enhancer); septum, aerial mycelium and fruiting body development; conidiation; ascosporogenesis; meiosis | X | X | X | X | [3] |
NcMOB2 | Tissue growth (enhancer); hypha development; conidiation | X | X | X | [3] | ||
NcMOB4 | Tissue growth (enhancer); fruiting body development; vegetative cell fusion | X | X | [3,24] | |||
AnMOB4 | Tissue growth (suppressor); ascosporogenesis; meiosis. | X | X | X | [22] | ||
SmMOB4 | Vegetative cell fusion; conidiation and ascosporogenesis; meiosis | X | X | X | [23] | ||
ChMOB2 | Conidiation and ascosporogenesis; meiosis | X | X | [4] |
P48 | D52 | W56 | N69 | M87 | A89 | A111 | Y114 | F132 | P133 | Y163 | F186 | F189 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identity in MOB proteins (multicellular) | 100% | 84% | 100% | 93% | 100% | 67% | 98% | 96% | 98% | 100% | 91% | 84% | 84% |
Identity in MOB proteins (unicellular) | 97% | 67% | 94% | 64% | 92% | 78% | 100% | 92% | 92% | 89% | 92% | 89% | 86% |
E33 | T35 | G37 | S38 | A44 | E51 | D63 | Q67 | M70 | T76 | Y92 | E93 | S110 | D126 | S182 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identity in MOB1-Like proteins (multicellular) | 50% | 94% | 88% | 100% | 100% | 94% | 100% | 94% | 69% | 81% | 81% | 94% | 94% | 94% | 75% |
Identity in MOB1-Like proteins (unicellular) | 36% | 100% | 100% | 73% | 91% | 100% | 73% | 55% | 27% | 45% | 91% | 100% | 82% | 64% | 45% |
E55 | A59 | Y72 | W97 | D128 | F140 | P141 | F144 | N180 | H185 | E192 | L207 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Identity in non phocein-like MOB proteins (multicellular) | 74% | 97% | 85% | 94% | 74% | 100% | 94% | 100% | 94% | 91% | 82% | 74% |
Identity in non phocein-like MOB proteins (unicellular) | 80% | 83% | 80% | 90% | 80% | 77% | 97% | 100% | 100% | 97% | 77% | 83% |
C79 | C84 | H161 | H166 | |
---|---|---|---|---|
Identity in MOB proteins (multicellular) | 100% | 100% | 100% | 100% |
Identity in MOB proteins (unicellular) | 97% | 94% | 100% | 100% |
T12 | Y26 | T35 | S38 | S146 | |
---|---|---|---|---|---|
Identity in Mob1-like proteins (multicellular) | 75% | 63% | 94% | 100% | 44% |
Identity in Mob1-like proteins (unicellular) | - | 45% | 100% | 73% | 27% |
Y141 | S147 | |
---|---|---|
Identity in phocein-like proteins (multicellular) | 73% | 73% |
Identity in phocein-like proteins (unicellular) | 0% | 40% |
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Delgado, I.L.S.; Carmona, B.; Nolasco, S.; Santos, D.; Leitão, A.; Soares, H. MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis. Biology 2020, 9, 413. https://doi.org/10.3390/biology9120413
Delgado ILS, Carmona B, Nolasco S, Santos D, Leitão A, Soares H. MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis. Biology. 2020; 9(12):413. https://doi.org/10.3390/biology9120413
Chicago/Turabian StyleDelgado, Inês L. S., Bruno Carmona, Sofia Nolasco, Dulce Santos, Alexandre Leitão, and Helena Soares. 2020. "MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis" Biology 9, no. 12: 413. https://doi.org/10.3390/biology9120413