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Open AccessConcept Paper

Cryptic Genetic Variation in Evolutionary Developmental Genetics

School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
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Academic Editors: John S. Torday and Jukka Finne
Biology 2016, 5(2), 28; https://doi.org/10.3390/biology5020028
Received: 11 April 2016 / Revised: 1 June 2016 / Accepted: 6 June 2016 / Published: 13 June 2016
(This article belongs to the Special Issue Beyond the Modern Evolutionary Synthesis- what have we missed?)
Evolutionary developmental genetics has traditionally been conducted by two groups: Molecular evolutionists who emphasize divergence between species or higher taxa, and quantitative geneticists who study variation within species. Neither approach really comes to grips with the complexities of evolutionary transitions, particularly in light of the realization from genome-wide association studies that most complex traits fit an infinitesimal architecture, being influenced by thousands of loci. This paper discusses robustness, plasticity and lability, phenomena that we argue potentiate major evolutionary changes and provide a bridge between the conceptual treatments of macro- and micro-evolution. We offer cryptic genetic variation and conditional neutrality as mechanisms by which standing genetic variation can lead to developmental system drift and, sheltered within canalized processes, may facilitate developmental transitions and the evolution of novelty. Synthesis of the two dominant perspectives will require recognition that adaptation, divergence, drift and stability all depend on similar underlying quantitative genetic processes—processes that cannot be fully observed in continuously varying visible traits. View Full-Text
Keywords: evolution; development; genetics; quantitative genetics; cryptic genetic variation evolution; development; genetics; quantitative genetics; cryptic genetic variation
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Paaby, A.B.; Gibson, G. Cryptic Genetic Variation in Evolutionary Developmental Genetics. Biology 2016, 5, 28.

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