Next Article in Journal
A Multi-Functional Tubulovesicular Network as the Ancestral Eukaryotic Endomembrane System
Previous Article in Journal
Recent Advances in the Analysis of Macromolecular Interactions Using the Matrix-Free Method of Sedimentation in the Analytical Ultracentrifuge
Article Menu

Export Article

Open AccessArticle
Biology 2015, 4(2), 251-263;

Modulation of Group I Ribozyme Activity by Cationic Porphyrins

Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Gofuku 3190, Toyama 930-8555, Japan
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka 819-0395, Japan
Center for Molecular Systems, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka 819-0395, Japan
Author to whom correspondence should be addressed.
Academic Editor: Chris O'Callaghan
Received: 1 December 2014 / Accepted: 3 March 2015 / Published: 24 March 2015
Full-Text   |   PDF [343 KB, uploaded 24 March 2015]   |  


The effects of cationic porphyrins on the catalytic activities of four group I ribozymes were investigated. A cationic porphyrin possessing four pyridinium moieties (pPyP) inhibited two group IC3 ribozymes (Syn Rz and Azo Rz) and a group IC1 ribozyme (Tet Rz). In the case of a group IA2 ribozyme (Td Rz), however, pPyP served not only as an inhibitor but also as an activator, and the effects of pPyP were dependent on its concentration. To analyze the structural and electronic factors determining the effects of pPyP on group I ribozymes, three cationic porphyrins (pPyNCP, pPyF4P, and TMPyP) were also examined. As interactions between small organic molecules and nucleic acids are attractive and important issues in biochemistry and biotechnology, this study contributes to the development of porphyrin-based molecules that can modulate functions of structured RNA molecules. View Full-Text
Keywords: RNA; ribozyme; porphyrin RNA; ribozyme; porphyrin

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Matsumura, S.; Ito, T.; Tanaka, T.; Furuta, H.; Ikawa, Y. Modulation of Group I Ribozyme Activity by Cationic Porphyrins. Biology 2015, 4, 251-263.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top