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Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London, WC1E 7HX, UK
* Author to whom correspondence should be addressed.
Received: 12 April 2013; in revised form: 21 May 2013 / Accepted: 24 May 2013 / Published: 26 June 2013
Abstract: Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-competent state, and an outer membrane-spanning nanomachine, the usher, which choreographs their assembly into a pilus and drives their secretion through the membrane. In this review, recent structures and kinetic studies are combined to examine the mechanism of type I and P pili assembly, as it is currently known. We also investigate how the knowledge of pilus biogenesis mechanisms has been exploited to design selective inhibitors of the process.
Keywords: chaperone-usher pathway; type I and P pilus; chaperone; usher; donor-strand complementation; donor-strand exchange; pilicide
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Lillington, J.; Waksman, G. Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili. Biology 2013, 2, 841-860.
Lillington J, Waksman G. Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili. Biology. 2013; 2(3):841-860.
Lillington, James; Waksman, Gabriel. 2013. "Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili." Biology 2, no. 3: 841-860.