Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives
Abstract
:Simple Summary
Abstract
1. Introduction
2. Causes and Mechanisms Leading to Infertility
3. Limitations in The Current Conception Treatment
3.1. Multifetal Gestations and The Effects
3.2. Ectopic Pregnancy
3.3. Ovarian Hyperstimulation Syndrome (OHSS)
3.4. Birth Defects
3.5. Cryopreservation of Testes and Ovary
4. MSCs and Their Mechanism in The Treatment of Infertility
5. Potential Usage of MSCs in Infertility
5.1. Preclinical Studies
5.2. Clinical Studies
Cell Source | Disease | Mode of Treatment | Outcome | Reference/ NCT ID |
---|---|---|---|---|
BMSCs | IUA (Asherman’s syndrome) | Transplantation in the endometrial cavity | Restoration of the menstrual cycle | [132] |
Increased endometrium thickness and good vascularity | [130] | |||
IUA (Asherman’s syndrome) | Intra-arterial to the uterus |
| [131] | |
IUA (Asherman’s syndrome) | BMSCs-loaded collagen scaffold |
| [133] | |
IUA (Asherman’s syndrome) | Transplantation to the uterine cavity | Recovered endometrium | [148] | |
POI | Laparoscopic instillation into ovaries |
| [149] | |
Injection into the ovary |
| [128] | ||
| [129] | |||
| NCT03069209 | |||
| NCT02043743 | |||
| NCT02062931 | |||
Injection via peripheral vein | No results posted (unknown status) | NCT02779374 | ||
Azoospermia | Injection into rete testis |
| [137] | |
Azoospermia | Intra-testicular transplantation | No results posted (recruiting) | NCT02641769 | |
Azoospermia (Klinefelter Syndrome) | Injection into testicular tubules and artery | No results posted (recruiting) | NCT02414295 | |
Non-obstructive azoospermia | Injection into testis | No results posted (recruiting) | NCT02041910 | |
Non-obstructive azoospermia | Injection into testis | No results posted (recruiting) | NCT02008799 | |
Ovarian reserve | Intra-ovarian artery injection |
| [135] | |
ADSCs | Thin endometrium syndrome | Subendometrial injection |
| [140] |
IUA (Asherman’s syndrome) | Transcervical instillation |
| [139] | |
Azoospermia and oligozoospermia | Injection into testis | No results posted (Enrolling by invitation) | NCT03762967 | |
POI | Intra ovarian transplantation |
| [138] | |
POI and Ovarian Ageing | Injection into ovary |
| [150] | |
Post-cancer surgical removal of erectile dysfunction | Single intracavernous injection | Improved erectile function | [141] | |
MenSCs | IUA (Asherman’s syndrome) | Transplanted into uterus | Regenerating the endometrium, prolonging menstrual duration, and increasing the rate of pregnancy | [142] |
Transplantation |
| [143] | ||
Endometrial-MSCs | Thin endometrium syndrome | Submucosal injection |
| [146] |
6. New Strategies and Future Perspectives
6.1. Cell-Free Therapy
6.1.1. MSCs-Derived Exosomes/miRNA
6.1.2. ADSCs-Derived Exosomes/miRNA
6.1.3. Menstrual SCs-Derived Exosomes/miRNA
6.2. Very Small Embryonic-like Stem Cells (VSELs)
6.3. Regenerative Therapy
7. Conclusion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Common Causes of Male Infertility | Common Causes of Female Infertility |
---|---|
Hypothalamic hypophyseal causes | Ovulation Disorders Causes |
Pituitary insufficiency | Ageing (diminished ovarian reserve) |
Hyperprolactinemia | Premature ovarian failure/insufficiency (POF/POI) |
Kallmann’s syndrome (anosmia) | Endocrine disorders (such as PCOS) |
Testicular Disorders | Tubal Causes |
Klinefelter syndrome | Pelvic inflammatory disease |
Chromosome anomalies (AZF microdeletions) | Tubal surgery |
Testicular atrophy | Previous ectopic pregnancy |
Varicocele (excessive heats) | Salpingectomy |
Cryptorchidism | Uterine/Cervical Causes |
Infections (such as mumps) | Congenital uterine anomaly |
Disorders of the Seminal Tract | Fibroids (Asherman’s syndrome) |
Retrograde Ejaculation | Endometriosis |
Obstructive azoospermia | Poor cervical mucus quality/quantity |
Immunological causes | Infection (salpingitis) |
Autoimmunity to sperm | Others |
Tumours/treatment | |
Obesity | |
Environment |
Cell Source | Disease | Mode of Treatment | Model | Outcome | Reference |
---|---|---|---|---|---|
ADSCs | POI (aging mice) | Microinjection into oocytes | Mice |
| [98] |
POI (aging mice) | Microinjection into oocytes | Mice | Did not mitigate the poor fertilization and embryonic development rates of aged oocytes | [99] | |
POI | Melatonin-pretreated intraovarian injection | Mouse |
| [126] | |
BMSCs | Testicular damage due to chemotherapy | Injection into the testes | Rats |
| [127] |
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Mohamed Rasheed, Z.B.; Nordin, F.; Wan Kamarul Zaman, W.S.; Tan, Y.-F.; Abd Aziz, N.H. Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives. Biology 2023, 12, 108. https://doi.org/10.3390/biology12010108
Mohamed Rasheed ZB, Nordin F, Wan Kamarul Zaman WS, Tan Y-F, Abd Aziz NH. Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives. Biology. 2023; 12(1):108. https://doi.org/10.3390/biology12010108
Chicago/Turabian StyleMohamed Rasheed, Zahirrah Begam, Fazlina Nordin, Wan Safwani Wan Kamarul Zaman, Yuen-Fen Tan, and Nor Haslinda Abd Aziz. 2023. "Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives" Biology 12, no. 1: 108. https://doi.org/10.3390/biology12010108