Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals
2.2. The Seed Butter from “Bacuri” (Platonia insignis Mart.)
2.3. Experimental Diabetes Induction
2.4. Biochemical Assays
2.5. Histopathology
2.6. Statistical Analysis
3. Results
3.1. Effect of Bacuri Seed Butter (Platonia insignis Mart.) Treatment on Body Weight and Food Intake
3.2. Effects of Bacuri Seed Butter (BSB) (Platonia insignis Mart.) on Fast Blood Glucose Levels and Glycated Hemoglobin (HbA1c) Percentage
3.3. Effects of Bacuri Seed Butter (BSB) (Platonia insignis Mart.) on Biomarkers of Liver and Kidney Function
3.4. Effects of Bacuri Seed Butter (BSB) (Platonia insignis Mart.) on Lipid Peroxidation and Myeloperoxidase Activity in Plasma and Liver
3.5. Effect of Bacuri Seed Butter (Platonia insignis Mart.) on Antioxidant Compounds
3.6. Morphological Changes in Liver Tissue of Diabetic Animals Treated with Bacuri Seed Butter (BSB) (Platonia insignis Mart.)
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Normal Control | Diabetic Control | BSB | Insulin NPH 6 UI/Animal/Day | |||
---|---|---|---|---|---|---|
25 mg/kg | 50 mg/kg | 100 mg/kg | ||||
Body weight gain (g) | 12.4 ± 2.5 | −31.2 ± 4.8 a | −31.6 ± 7.5 a | −25.1 ± 3.1 a | −35.6 ± 6.3 a | 28.4 ± 2.9 b |
Food Intake (g) | 14.8 ± 0.4 | 35.9 ± 1.07 a | 32.4 ± 1.2 a | 31.7 ± 1.3 a | 32.9 ± 1.4 a | 22.2 ± 0.5 ab |
Group | Fast Blood Glucose (mg/dL) | |||
---|---|---|---|---|
First Week | Second Week | Third Week | Fourth Week | |
Normal control | 87.8 ± 4.3 | 99.6 ± 2.5 | 95.14 ± 4.1 | 91.43 ± 3.0 |
Diabetic control | 477.0 ± 18.7 a | 515.0 ± 27.3 a | 515.4 ± 29.7 a | 539.7 ± 29.9 a |
BSB 25 mg/kg | 509.4 ± 25.4 a | 514.6 ± 22.3 a | 497.8 ± 36.3 a | 470.2 ± 22.3 a |
BSB 50 mg/kg | 468.8 ± 32.9 a | 543.2 ± 35.6 a | 600.0 ± 0.0 a | 554.2 ± 29.2 a |
BSB 100 mg/kg | 486.4 ± 34.5 a | 497.8 ± 43.8 a | 532.0 ± 20.7 a | 571.2 ± 16.2 a |
NPH insulin | 474.6 ± 20.4 a | 477.2 ± 19.4 a | 480.8 ± 30.1 a | 514.0 ± 31.8 a |
Normal Control | Diabetic Control | BSB | Insulin NPH 6 UI/Animal/Day | |||
---|---|---|---|---|---|---|
25 mg/kg | 50 mg/kg | 100 mg/kg | ||||
ALT (U/L) | 47.00 ± 3.6 | 325.2 ± 26.9 a | 229.3 ± 17.3 ab | 195.3 ± 17.7 ab | 137.6 ± 21.6 ab | 62.0 ± 14.97 b |
AST (U/L) | 111.1 ± 5.3 | 678.3 ± 64.6 a | 329.3 ± 59.1 ab | 287.5 ± 32.8 b | 192.6 ± 20.4 b | 161.2 ± 45.9 b |
Albumin (g/dL) | 2.4 ± 0.1 | 1.77 ± 0.1 a | 1.88 ± 0.1 a | 1.8 ± 0.1 a | 2.2 ± 0.1 b | 2.1 ± 0.1 |
Liver relative weight (g) | 2.9 ± 0.1 | 4.09 ± 0.1 a | 4.97 ± 0.2 a | 4.8 ± 0.1 a | 4.96 ± 0.1 a | 3.7 ± 0.2 ab |
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Lindoso, J.V.d.S.; Alencar, S.R.; Santos, A.A.d.; Mello Neto, R.S.; Mendes, A.V.d.S.; Furtado, M.M.; Silva, M.G.d.; Brito, A.K.d.S.; Batista, E.K.F.; Baêta, S.d.A.F.; et al. Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats. Biology 2022, 11, 562. https://doi.org/10.3390/biology11040562
Lindoso JVdS, Alencar SR, Santos AAd, Mello Neto RS, Mendes AVdS, Furtado MM, Silva MGd, Brito AKdS, Batista EKF, Baêta SdAF, et al. Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats. Biology. 2022; 11(4):562. https://doi.org/10.3390/biology11040562
Chicago/Turabian StyleLindoso, Jéssica Vanessa dos Santos, Salmon Rocha Alencar, Andressa Amorim dos Santos, Renato Sampaio Mello Neto, Ana Victória da Silva Mendes, Mariely Mendes Furtado, Maisa Gomes da Silva, Ana Karolinne da Silva Brito, Emanuelle Karine Frota Batista, Silvia de Araújo França Baêta, and et al. 2022. "Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats" Biology 11, no. 4: 562. https://doi.org/10.3390/biology11040562
APA StyleLindoso, J. V. d. S., Alencar, S. R., Santos, A. A. d., Mello Neto, R. S., Mendes, A. V. d. S., Furtado, M. M., Silva, M. G. d., Brito, A. K. d. S., Batista, E. K. F., Baêta, S. d. A. F., Moreira Nunes, P. H., Lucarini, M., Durazzo, A., Arcanjo, D. D. R., & Martins, M. d. C. d. C. e. (2022). Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats. Biology, 11(4), 562. https://doi.org/10.3390/biology11040562