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Article

Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats

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Graduate Program in Health Science, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
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Graduate Program of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
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Group of Studies and Research of Performance, Sport, Health and Paralympic Sports (GEPEPS), Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
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Department of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
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Graduate Program of Physiological Science, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
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Laboratory of Morphology and Experimental Pathology, University Tiradentes (UNIT), Aracaju 49010-390, Brazil
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Cardiovascular & Physiology of Exercise Laboratory, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
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Graduate Program on Biomedical Engineering, Federal Technological University of Paraná (PPGEB/UTFPR), Curitiba 80230-901, Brazil
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Department of Physical Education, State University of Montes Claros, Montes Claros 39401-089, Brazil
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Department of Physical Education, Federal University of Rio Grande do Norte, Natal 59064-741, Brazil
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Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland
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Medbase St. Gallen Am Vadianplatz, 9001 St. Gallen, Switzerland
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Escola Superior Desporto e Lazer, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun’Álvares, 4900-347 Viana do Castelo, Portugal
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Instituto de Telecomunicações, Delegação da Covilhã, 1049-001 Lisboa, Portugal
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Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil
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Author to whom correspondence should be addressed.
Academic Editor: Carlo Reggiani
Biology 2022, 11(1), 32; https://doi.org/10.3390/biology11010032
Received: 22 October 2021 / Revised: 15 December 2021 / Accepted: 18 December 2021 / Published: 27 December 2021
Spinal Cord Injury is a devastating condition that compromises the individual’s health, quality of life and functional independence. Rats submitted to Spinal Cord Injury were evaluated after four weeks of resistance training. Analyses of levels of muscle damage and oxidative stress surgery were performed. Resistance training demonstrated increase antioxidative activity while decreased oxidative damage in injured rats, in addition to having presented changes in the levels of muscle damage in that same group. The results highlight that resistance training promoted a decrease in oxidative stress and a significant response in muscle damage markers.
Background: Spinal cord injury (SCI) is a condition that affects the central nervous system, is characterized by motor and sensory impairments, and impacts individuals’ lives. The objective of this study was to evaluate the effects of resistance training on oxidative stress and muscle damage in spinal cord injured rats. Methodology: Forty Wistar rats were selected and divided equally into five groups: Healthy Control (CON), Sham (SHAM) SCI Untrained group (SCI-U), SCI Trained group (SCI- T), SCI Active Trained group (SCI- AT). Animals in the trained groups were submitted to an incomplete SCI at T9. Thereafter, they performed a protocol of resistance training for four weeks. Results: Significant differences in muscle damage markers and oxidative stress in the trained groups, mainly in SCI- AT, were found. On the other hand, SCI- U group presented higher levels of oxidative stress and biomarkers of LDH and AST. Conclusion: The results highlight that resistance training promoted a decrease in oxidative stress and a significative response in muscle damage markers. View Full-Text
Keywords: spinal cord injury; resistance training; oxidative stress; muscle damage spinal cord injury; resistance training; oxidative stress; muscle damage
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MDPI and ACS Style

Barros, N.d.A.; Aidar, F.J.; Marçal, A.C.; Santos, J.L.; de Souza, R.F.; Menezes, J.L.; Gomes, M.Z.; de Matos, D.G.; Neves, E.B.; Carneiro, A.L.G.; de Almeida-Neto, P.F.; de Araújo Tinoco Cabral, B.G.; Belo Neto, R.V.; Knechtle, B.; Clemente, F.M.; Camargo, E.A. Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats. Biology 2022, 11, 32. https://doi.org/10.3390/biology11010032

AMA Style

Barros NdA, Aidar FJ, Marçal AC, Santos JL, de Souza RF, Menezes JL, Gomes MZ, de Matos DG, Neves EB, Carneiro ALG, de Almeida-Neto PF, de Araújo Tinoco Cabral BG, Belo Neto RV, Knechtle B, Clemente FM, Camargo EA. Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats. Biology. 2022; 11(1):32. https://doi.org/10.3390/biology11010032

Chicago/Turabian Style

Barros, Natalie d.A., Felipe J. Aidar, Anderson C. Marçal, Jymmys L. Santos, Raphael F. de Souza, Jainara L. Menezes, Margarete Z. Gomes, Dihogo G. de Matos, Eduardo B. Neves, André L.G. Carneiro, Paulo F. de Almeida-Neto, Breno G. de Araújo Tinoco Cabral, Reinaldo V. Belo Neto, Beat Knechtle, Filipe M. Clemente, and Enilton A. Camargo. 2022. "Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats" Biology 11, no. 1: 32. https://doi.org/10.3390/biology11010032

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