The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer
Abstract
Simple Summary
Abstract
1. Introduction
1.1. Angiogenesis and Cancer
1.2. Angiogenesis and Gastric Cancer
1.3. MicroRNAs and Cancer
1.4. MicroRNAs and Angiogenesis
2. Materials and Methods
3. Results
3.1. MicroRNAs Involved in the VEGF Pathway
3.2. MicroRNAs Involved in the HIF Pathway
3.3. MicroRNAs Involved in HGF/c-MET Signaling
3.4. MicroRNAs Involved in the PI3K Pathway
3.4.1. MicroRNAs Targeting PTEN
3.4.2. MicroRNAs Targeting FOXO
3.4.3. MicroRNAs Targeting mTOR
3.4.4. MicroRNAs Targeting NF-κB
3.5. MicroRNAs Involved in STAT-3 Signaling
miRNA | Target Genes | Classification | Reference |
---|---|---|---|
miR-1 | VEGF-A EDN1 MET | VEGF pathway | Azarbarzin et al., 2020 [23] |
miR-29a/c | VEGF | VEGF pathway | Zhang et al., 2016 [64] |
miR-27b | VEGF-C | VEGF pathway | Liu et al., 2015 [65] |
miR-101 | |||
miR-128 | |||
miR-126 | VEGF-A | VEGF pathway | Cuzziol et al., 2020 [62] Yang et al., 2015 [63] |
miR-590 | VEGFR1/2 NRP1 | VEGF pathway | Mei et al., 2020 [66] |
miR-210 | HIF | HIF pathway | Seo et al., 2019 [68] |
miR-574-5p | PTPN3 | HIF pathway | Azarbarzin et al., 2020 [23] Zhang et al., 2020 [67] |
miR-616-3p | PTEN | PI3K pathway VEGF pathway | Wu et al., 2018 [60] |
miR-26a/b | HGF | HGF/c-MET signaling | Si et al., 2017 [69] |
miR-18a | mTOR | PI3K pathway | Yang et al., 2015 [63] |
miR-23a | PTEN | PI3K pathway | Azarbarzin et al., 2020 [23] Du et al., 2020 [70] |
miR-101-2 | mTOR/PIK3CB/TSC1 | PI3K pathway | Riquelme et al., 2016 [76] |
miR-125b-2 | PI3K pathway | ||
miR-451a | PI3K pathway | ||
miR-135b | FOXO1 | PI3K pathway | Bai et al., 2019 [74] |
miR-382 | PTEN | PI3K pathway | Du et al., 2020 [70] Seo et al., 2019 [68] |
miR-532-5p | NCF2 | PI3K pathway | Zhang et al., 2018 [75] |
miR-718 | PTEN | PI3K pathway | Du et al., 2020 [70] |
miR-155 | c-MYB/VEGF FOXO3a | Other—c-MYB PI3K pathway | Azarbarzin et al., 2020 [23] Deng et al., 2020 [72] Zhou et al., 2019 [73] |
miR-874 | STAT-3/VEGF-A | STAT-3 signaling | Cuzziol et al., 2020 [62] Zhang et al., 2015 [78] |
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Giuppi, M.; La Salvia, A.; Evangelista, J.; Ghidini, M. The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer. Biology 2021, 10, 146. https://doi.org/10.3390/biology10020146
Giuppi M, La Salvia A, Evangelista J, Ghidini M. The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer. Biology. 2021; 10(2):146. https://doi.org/10.3390/biology10020146
Chicago/Turabian StyleGiuppi, Martina, Anna La Salvia, Jessica Evangelista, and Michele Ghidini. 2021. "The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer" Biology 10, no. 2: 146. https://doi.org/10.3390/biology10020146
APA StyleGiuppi, M., La Salvia, A., Evangelista, J., & Ghidini, M. (2021). The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer. Biology, 10(2), 146. https://doi.org/10.3390/biology10020146