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Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

1
Laboratorio Oncovirología, Programa de Virología, Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago 8380000, Chile
2
Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile
3
Centro Universitario del Sur, Laboratorio de Ciencias Fisiológicas, Departamento de Ciencias Básicas para la Salud, Universidad de Guadalajara, Guadalajara 44100, Mexico
4
Advanced Center for Chronic Diseases (ACCDIS), Pontificia Universidad Católica de Chile, Santiago 8320000, Chile
5
Departamento de Oncología Básico Clínica (DOBC), Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile
6
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
7
Instituto de Alta Investigación, Sede Esmeralda, Universidad de Tarapacá, Iquique 1101783, Chile
*
Author to whom correspondence should be addressed.
Equally contributed.
Biology 2021, 10(2), 116; https://doi.org/10.3390/biology10020116
Received: 1 December 2020 / Revised: 8 January 2021 / Accepted: 14 January 2021 / Published: 4 February 2021
(This article belongs to the Section Cancer Biology)
Pirin is a protein which is detected at low levels in normal tissues. However, it is detected at high levels in multiple cancers, particularly in melanomas, cervical cancer or squamous cell lung carcinomas. Essentially, its role in cancer is related to the host response against factors causing oxidative stress, favoring cell migration and metastasis. Here we summarize the biological functions of Pirin in relation to its role in cancer, suggesting that Pirin is a potential therapeutic target.
Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains a novel area of study. This review presents accumulating evidence on the contribution of Pirin in epithelial cancers, involved signaling pathways, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development. View Full-Text
Keywords: pirin; cancer; epithelial pirin; cancer; epithelial
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MDPI and ACS Style

Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Corvalan, A.H.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Biology 2021, 10, 116. https://doi.org/10.3390/biology10020116

AMA Style

Perez-Dominguez F, Carrillo-Beltrán D, Blanco R, Muñoz JP, León-Cruz G, Corvalan AH, Urzúa U, Calaf GM, Aguayo F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Biology. 2021; 10(2):116. https://doi.org/10.3390/biology10020116

Chicago/Turabian Style

Perez-Dominguez, Francisco, Diego Carrillo-Beltrán, Rancés Blanco, Juan P. Muñoz, Grettell León-Cruz, Alejandro H. Corvalan, Ulises Urzúa, Gloria M. Calaf, and Francisco Aguayo. 2021. "Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis" Biology 10, no. 2: 116. https://doi.org/10.3390/biology10020116

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