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Methods, Challenges and Potentials of Single Cell RNA-seq

The University of Warwick, School of Life Sciences, Coventry CV4 7AL, UK
Biology 2012, 1(3), 658-667; https://doi.org/10.3390/biology1030658
Received: 24 October 2012 / Revised: 24 October 2012 / Accepted: 7 November 2012 / Published: 16 November 2012
(This article belongs to the Special Issue Next Generation Sequencing Approaches in Biology)
RNA-sequencing (RNA-seq) has become the tool of choice for transcriptomics. Several recent studies demonstrate its successful adaption to single cell analysis. This allows new biological insights into cell differentiation, cell-to-cell variation and gene regulation, and how these aspects depend on each other. Here, I review the current single cell RNA-seq (scRNA-seq) efforts and discuss experimental protocols, challenges and potentials. View Full-Text
Keywords: RNA-seq; scRNA-seq; single cell RNA-seq; scRNA-seq; single cell
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Hebenstreit, D. Methods, Challenges and Potentials of Single Cell RNA-seq. Biology 2012, 1, 658-667.

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