Electrochemical Detection of Dopamine Based on Functionalized Electrodes
by
Mathieu Ouellette 1
, Jessy Mathault 2, Shimwe Dominique Niyonambaza 1,2, Amine Miled 2 and Elodie Boisselier 1,*
, Jessy Mathault 2, Shimwe Dominique Niyonambaza 1,2, Amine Miled 2 and Elodie Boisselier 1,*
1
CUO-Recherche, Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, Département d’ophtalmologie, Faculté de médecine, Université Laval, Québec, QC G3K 1A3, Canada
2
Electrical and Computer Engineering Department, Faculty of Sciences and Engineering, Université Laval, Québec, QC G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
Coatings 2019, 9(8), 496; https://doi.org/10.3390/coatings9080496
Received: 28 June 2019 / Revised: 28 July 2019 / Accepted: 2 August 2019 / Published: 6 August 2019
(This article belongs to the Special Issue Nanoparticles and Nanostructured Coatings: Synthesis, Processing and Applications)
The rapid electrochemical identification and quantification of neurotransmitters being a challenge in the ever-growing field of neuroelectronics, we aimed to facilitate the electrochemical selective detection of dopamine by functionalizing commercially available electrodes through the deposition of a thin film containing pre-formed gold nanoparticles. The influence of different parameters and experimental conditions, such as buffer solution, fiber material, concentration, and cyclic voltammetry (CV) cycle number, were tested during neurotransmitter detection. In each case, without drastically changing the outcome of the functionalization process, the selectivity towards dopamine was improved. The detected oxidation current for dopamine was increased by 92%, while ascorbic acid and serotonin oxidation currents were lowered by 66% under the best conditions. Moreover, dopamine sensing was successfully achieved in tandem with home-made triple electrodes and an in-house built potentiostat at a high scan rate mode.
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MDPI and ACS Style
Ouellette, M.; Mathault, J.; Niyonambaza, S.D.; Miled, A.; Boisselier, E. Electrochemical Detection of Dopamine Based on Functionalized Electrodes. Coatings 2019, 9, 496.
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