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Nanochannelar Topography Positively Modulates Osteoblast Differentiation and Inhibits Osteoclastogenesis

1
Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splial Independentei, 050095 Bucharest, Romania
2
Department of Materials Science, University of Erlangen-Nuremberg, WW-4, LKO, Matersstr 7, 91058 Erlangen, Germany
3
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Str. Gheorghe Polizu 1-7, 011061 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Coatings 2018, 8(9), 294; https://doi.org/10.3390/coatings8090294
Received: 18 July 2018 / Revised: 13 August 2018 / Accepted: 20 August 2018 / Published: 21 August 2018
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Abstract

Based on previously reported findings showing reduced foreign body reactions on nanochannelar topography formed on TiZr alloy, this study explores the in vitro effects of such a nanostructured surface on cells relevant for implant osseointegration, namely osteoblasts and osteoclasts. We show that such nanochannelar surfaces sustain adhesion and proliferation of mouse pre-osteoblast MC3T3-E1 cells and enhance their osteogenic differentiation. Moreover, this specific nanotopography inhibits nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis. The nanochannels’ dual mode of action on the bone-derived cells could contribute to an enhanced bone formation around the bone implants. Therefore, these results warrant further investigation for nanochannels’ use as surface coatings of medical implant materials. View Full-Text
Keywords: topography; nanochannels; osteoblast; macrophage; osteoclast topography; nanochannels; osteoblast; macrophage; osteoclast
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Ion, R.; Mazare, A.; Dumitriu, C.; Pirvu, C.; Schmuki, P.; Cimpean, A. Nanochannelar Topography Positively Modulates Osteoblast Differentiation and Inhibits Osteoclastogenesis. Coatings 2018, 8, 294.

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