Next Article in Journal
Tribological, Tribocorrosion and Wear Mechanism Studies of TaZrN Coatings Deposited by Magnetron Sputtering on TiAlV Alloy
Previous Article in Journal
Effect of Oxygen Vacancy Ratio on a GaZTO Solar-Blind Photodetector
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle

Nanochannelar Topography Positively Modulates Osteoblast Differentiation and Inhibits Osteoclastogenesis

Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splial Independentei, 050095 Bucharest, Romania
Department of Materials Science, University of Erlangen-Nuremberg, WW-4, LKO, Matersstr 7, 91058 Erlangen, Germany
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Str. Gheorghe Polizu 1-7, 011061 Bucharest, Romania
Author to whom correspondence should be addressed.
Coatings 2018, 8(9), 294;
Received: 18 July 2018 / Revised: 13 August 2018 / Accepted: 20 August 2018 / Published: 21 August 2018
PDF [3004 KB, uploaded 22 August 2018]


Based on previously reported findings showing reduced foreign body reactions on nanochannelar topography formed on TiZr alloy, this study explores the in vitro effects of such a nanostructured surface on cells relevant for implant osseointegration, namely osteoblasts and osteoclasts. We show that such nanochannelar surfaces sustain adhesion and proliferation of mouse pre-osteoblast MC3T3-E1 cells and enhance their osteogenic differentiation. Moreover, this specific nanotopography inhibits nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis. The nanochannels’ dual mode of action on the bone-derived cells could contribute to an enhanced bone formation around the bone implants. Therefore, these results warrant further investigation for nanochannels’ use as surface coatings of medical implant materials. View Full-Text
Keywords: topography; nanochannels; osteoblast; macrophage; osteoclast topography; nanochannels; osteoblast; macrophage; osteoclast

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ion, R.; Mazare, A.; Dumitriu, C.; Pirvu, C.; Schmuki, P.; Cimpean, A. Nanochannelar Topography Positively Modulates Osteoblast Differentiation and Inhibits Osteoclastogenesis. Coatings 2018, 8, 294.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Coatings EISSN 2079-6412 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top