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Open AccessArticle

Degradation and In Vivo Response of Hydroxyapatite-Coated Mg Alloy

Medical Institute, Sumy State University, 2 R-Korsakova Str, 40007 Sumy, Ukraine
Department of General Chemistry, Sumy State University, 2 R-Korsakova Str, 40007 Sumy, Ukraine
Department of Therapy, Pharmacology, Clinical Diagnostics and Chemistry, Sumy National Agrarian University, 160 H. Kondratiev Str., 40021 Sumy, Ukraine
Osteoplant R & D, 25 Metalowkow Str., 39-200 Dębica, Poland
Institute of Applied Physics, National Academy of Sciences of Ukraine, 58 Petropavlovskaya St., 40030 Sumy, Ukraine
Author to whom correspondence should be addressed.
Coatings 2018, 8(11), 375;
Received: 24 June 2018 / Revised: 15 October 2018 / Accepted: 20 October 2018 / Published: 23 October 2018
Nowadays there is a need for new generation of biodegradable implants, which should be able to stimulate the healing responses of injured tissues at the molecular level. Magnesium alloys attract great attention as perspective bone implants due to their biocompatibility, physical properties and ability to degrade completely under physiological conditions. The main purpose of this research was assessment of in vitro corrosion and surface morphology after short term in vivo implantation of Mg based implant covered by hydroxyapatite (HA). Mg alloys with the addition of Zr (0.65%), Al (1.85%) and Nd (1.25%) were used. In our work, we propose dipping method for hydroxyapatite coatings formation which has been shown to reduce the corrosion rate of magnesium implants in vivo. Simulated body fluid (SBF; pH 7.4) with ion concentrations approximately equal to those of human blood plasma resembling physiological conditions and citrate buffer with pH 5—simulating inflammation were selected as modelling environments for in vitro degradation test. The rod samples were implanted into the tibia bone of rats and after 1 day and 5 days of implantation were taken out to observe cells adhesion on surface samples. SEM was used to assess surface morphology after in vitro and in vivo tests. SBF solution causes some cracks on the surface of HA coatings, while citrate solution at pH 2 caused complete dissolving of the coating. The HA coating favoured cell adhesion and rapid fibrous tissue formation. View Full-Text
Keywords: Mg alloy; corrosion; HA coating; implantation Mg alloy; corrosion; HA coating; implantation
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Husak, Y.; Solodovnyk, O.; Yanovska, A.; Kozik, Y.; Liubchak, I.; Ivchenko, V.; Mishchenko, O.; Zinchenko, Y.; Kuznetsov, V.; Pogorielov, M. Degradation and In Vivo Response of Hydroxyapatite-Coated Mg Alloy. Coatings 2018, 8, 375.

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