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Article

Porous ZnO/2–Hydroxyethyl Methacrylate Eluting Coatings for Ureteral Stent Applications

1
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129 Torino, Italy
2
Department of Polymer Chemistry, Maria Curie Sklodowska University, Gliniana 33, 20-614 Lublin, Poland
*
Author to whom correspondence should be addressed.
Coatings 2018, 8(11), 376; https://doi.org/10.3390/coatings8110376
Received: 14 September 2018 / Revised: 9 October 2018 / Accepted: 22 October 2018 / Published: 23 October 2018
High-surface-area porous coatings represent an interesting option to fabricate eluting stents with additional functionalities, as controlled drug delivery and antibacterial resistance properties. ZnO is a biocompatible material available in various high-surface-area morphologies, with promising antibacterial properties. Hydrophilic 2-hydroxyethyl methacrylate (HEMA) polymers (pHEMA) have been widely investigated for their biomedical applications, thanks to their biocompatibility, absence of toxicity, and tunable swelling properties. This work aims to demonstrate the use of porous ZnO/polymer bilayer coatings for future drug eluting stent applications. Sputtered mesoporous ZnO layers were coated with pHEMA and p(HEMA-co-acrylic acid (AA)) films through vacuum infiltration and drop-casting methods. The last approach was found to be the most suitable one for achieving a good polymer infiltration within the ZnO matrix and to avoid the mechanical detachment of the porous film from the substrate. The corresponding release properties were evaluated by loading a fluorescent dye in the host ZnO matrix, before drop-casting the polymer coating. For pure ZnO, the release of the dye was completed after 2 h. For ZnO/pHEMA, the sustained release of the molecule was achieved with only 30% released after 2 h and 100% released after seven days. In this case, the pH-triggered delivery properties were also demonstrated by switching from neutral to acidic pH conditions. No significant changes were obtained for the ZnO/p(HEMA-co-AA) system, which exhibited a faster swelling behavior and a release profile similar to pure ZnO. View Full-Text
Keywords: zinc oxide; porous thin films; 2-hydroxyethyl methacrylate; drug delivery; pH-triggered release; eluting coatings zinc oxide; porous thin films; 2-hydroxyethyl methacrylate; drug delivery; pH-triggered release; eluting coatings
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MDPI and ACS Style

Laurenti, M.; Grochowicz, M.; Cauda, V. Porous ZnO/2–Hydroxyethyl Methacrylate Eluting Coatings for Ureteral Stent Applications. Coatings 2018, 8, 376. https://doi.org/10.3390/coatings8110376

AMA Style

Laurenti M, Grochowicz M, Cauda V. Porous ZnO/2–Hydroxyethyl Methacrylate Eluting Coatings for Ureteral Stent Applications. Coatings. 2018; 8(11):376. https://doi.org/10.3390/coatings8110376

Chicago/Turabian Style

Laurenti, Marco, Marta Grochowicz, and Valentina Cauda. 2018. "Porous ZnO/2–Hydroxyethyl Methacrylate Eluting Coatings for Ureteral Stent Applications" Coatings 8, no. 11: 376. https://doi.org/10.3390/coatings8110376

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