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Article

Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials

1
Department of Chemistry and Biochemistry, Graduate School of Engineering, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
2
Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Roman A. Surmenev
Coatings 2021, 11(4), 461; https://doi.org/10.3390/coatings11040461
Received: 10 March 2021 / Revised: 14 April 2021 / Accepted: 14 April 2021 / Published: 16 April 2021
(This article belongs to the Special Issue Bioactive Coatings for Implantable Devices)
The regulation of adhesion and the subsequent behavior of fibroblast cells on the surface of biomaterials is important for successful tissue regeneration and wound healing by implanted biomaterials. We have synthesized poly(ω-methoxyalkyl acrylate)s (PMCxAs; x indicates the number of methylene carbons between the ester and ethyl oxygen), with a carbon chain length of x = 2–6, to investigate the regulation of fibroblast cell behavior including adhesion, proliferation, migration, differentiation and collagen production. We found that PMC2A suppressed the cell spreading, protein adsorption, formation of focal adhesion, and differentiation of normal human dermal fibroblasts, while PMC4A surfaces enhanced them compared to other PMCxAs. Our findings suggest that fibroblast activities attached to the PMCxA substrates can be modified by changing the number of methylene carbons in the side chains of the polymers. These results indicate that PMCxAs could be useful coating materials for use in skin regeneration and wound dressing applications. View Full-Text
Keywords: PMEA analog polymers; coating materials; fibroblasts; cell behavior; wound dressing PMEA analog polymers; coating materials; fibroblasts; cell behavior; wound dressing
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MDPI and ACS Style

Anjum, R.; Nishida, K.; Matsumoto, H.; Murakami, D.; Kobayashi, S.; Anada, T.; Tanaka, M. Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials. Coatings 2021, 11, 461. https://doi.org/10.3390/coatings11040461

AMA Style

Anjum R, Nishida K, Matsumoto H, Murakami D, Kobayashi S, Anada T, Tanaka M. Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials. Coatings. 2021; 11(4):461. https://doi.org/10.3390/coatings11040461

Chicago/Turabian Style

Anjum, Rubaiya, Kei Nishida, Haruka Matsumoto, Daiki Murakami, Shingo Kobayashi, Takahisa Anada, and Masaru Tanaka. 2021. "Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials" Coatings 11, no. 4: 461. https://doi.org/10.3390/coatings11040461

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