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The Impact of Curcumin on Bone Osteogenic Promotion of MC3T3 Cells under High Glucose Conditions and Enhanced Bone Formation in Diabetic Mice

1
Department of Orthodontics, School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, China
2
School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, China
3
Prosthodontics Department, Erbil Polytechnic University, Kurdistan Region, Erbil 44001, Iraq
*
Authors to whom correspondence should be addressed.
Coatings 2020, 10(3), 258; https://doi.org/10.3390/coatings10030258
Received: 6 February 2020 / Revised: 3 March 2020 / Accepted: 7 March 2020 / Published: 10 March 2020
(This article belongs to the Special Issue Recent Advances in Coatings of Implant and Dental Biomaterials)
Diabetic osteoporosis (DOP) is characterized by impaired bone microstructure and reduced bone density resulting from high glucose levels. Curcumin (CURC) is extensively applied in the treatment of inflammation-associated diseases. However, the effect of curcumin on bone metabolism in diabetic osteoporosis is unclear. Therefore, this study investigated the optimal concentration of curcumin on enhancing osteogenesis in diabetic osteoporosis. Osteoblasts were treated with a high or low concentration of curcumin under a series of concentrations of high-glucose conditions. Type 2 diabetic mice were intervened with curcumin. Cell proliferation, apoptosis, and osteogenesis-related gene expressions were evaluated by CCK-8, flow cytometry, and real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR). Bone formation was evaluated by histological staining. The findings revealed that curcumin suppressed apoptosis and enhanced proliferation and osteogenesis-related gene expressions of osteoblasts under high glucose concentrations (p < 0.05). The histological sections displayed reduced bone destruction and increased the growth rate of trabecular bone and the bone density of diabetic mice treated with curcumin, compared to diabetic mice. These results showed that curcumin could reverse the harmful effects of diabetic osteoporosis in a dose-dependent manner, and 10 μmol/L was regarded as the optimal concentration, which supports the potential use of curcumin for bone regeneration under high glucose concentrations. View Full-Text
Keywords: curcumin; high glucose; osteogenesis; bone formation; diabetic osteoporosis curcumin; high glucose; osteogenesis; bone formation; diabetic osteoporosis
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MDPI and ACS Style

He, J.; Yang, X.; Liu, F.; Li, D.; Zheng, B.; Abdullah, A.O.; Liu, Y. The Impact of Curcumin on Bone Osteogenic Promotion of MC3T3 Cells under High Glucose Conditions and Enhanced Bone Formation in Diabetic Mice. Coatings 2020, 10, 258.

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