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Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins

1
Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia
2
Laboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia
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Department of Bionanotechnology, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia
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Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia
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Department of General Mathematics and Informatics, Kemerovo State University, Krasnaya Street, 6, 650043 Kemerovo, Russia
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(9), 553; https://doi.org/10.3390/antibiotics9090553
Received: 20 July 2020 / Revised: 25 August 2020 / Accepted: 26 August 2020 / Published: 28 August 2020
(This article belongs to the Special Issue The Multi Functionality of Anti-Microbial Peptides)
This paper summarizes information about the division of bacteriocins into classes (Gram-negative bacteria, Gram-positive bacteria, and archaea). Methods for producing bacteriocins have been studied. It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. It is established that the main method of bacteriocin research is PCR analysis, which makes it possible to quickly and easily identify the presence of bacteriocin encoding genes. The mechanism of cytotoxic action of bacteriocins has been studied. It is proved that the study of cytotoxic (antitumor) activity in laboratory conditions will lead to the clinical use of bacteriocins for cancer treatment in the near future. It is established that the incorporation of bacteriocins into nanoparticles and targeted delivery to areas of infection may soon become an effective treatment method. The delivery of bacteriocins in a concentrated form, such as encapsulated in nanoparticles, will increase their effectiveness and minimize potential toxic side effects. The analysis of publications on this topic confirmed that diverse research on bacteriocins is relevant. View Full-Text
Keywords: bacteriocins; antimicrobial action; cytotoxic action; activity of bacteriocins; probiotics; PCR reactions bacteriocins; antimicrobial action; cytotoxic action; activity of bacteriocins; probiotics; PCR reactions
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MDPI and ACS Style

Zimina, M.; Babich, O.; Prosekov, A.; Sukhikh, S.; Ivanova, S.; Shevchenko, M.; Noskova, S. Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins. Antibiotics 2020, 9, 553. https://doi.org/10.3390/antibiotics9090553

AMA Style

Zimina M, Babich O, Prosekov A, Sukhikh S, Ivanova S, Shevchenko M, Noskova S. Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins. Antibiotics. 2020; 9(9):553. https://doi.org/10.3390/antibiotics9090553

Chicago/Turabian Style

Zimina, Maria; Babich, Olga; Prosekov, Alexander; Sukhikh, Stanislav; Ivanova, Svetlana; Shevchenko, Margarita; Noskova, Svetlana. 2020. "Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins" Antibiotics 9, no. 9: 553. https://doi.org/10.3390/antibiotics9090553

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