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Profile of Enterobacteria Resistant to Beta-Lactams

Institute of Tropical Pathology and Public Health, Federal University of Goiás, 235 Street, Goiânia 74605-050, Brazil
Agency of Agricultural Defense of Paraná—ADAPAR, Goioerê 80035-050, Brazil
Medicine College, Federal University of Goiás, 235 Street, Goiânia 74690-900, Brazil
Laranjeiras Unit, State University of Goiás, Goiânia 74705-010, Brazil
Department of Biology, Federal University of Tocantins, Square 109 North, NS15 Avenue, ALCNO-14-Plano Director North, Palmas 77001-090, Brazil
Department of Biology, Pontifical Catholic University of Goiás, 1st Avenue, Goiânia 74175-120, Brazil
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(7), 410;
Received: 28 February 2020 / Revised: 9 April 2020 / Accepted: 10 April 2020 / Published: 15 July 2020
(This article belongs to the Special Issue Antibiotic Resistance: From the Bench to Patients)
A serious emerging problem worldwide is increased antimicrobial resistance. Acquisition of coding genes for evasion methods of antimicrobial drug mechanisms characterizes acquired resistance. This phenomenon has been observed in Enterobacteriaceae family. Treatment for bacterial infections is performed with antibiotics, of which the most used are beta-lactams. The aim of this study was to correlate antimicrobial resistance profiles in Enterobacteriaceae by phenotypic methods and molecular identification of 14 beta-lactamase coding genes. In this study, 70 exclusive isolates from Brazil were used, half of which were collected in veterinary clinics or hospitals Phenotypic methodologies were used and real-time PCR was the molecular methodology used, through the Sybr Green system. Regargding the results found in the tests it was observed that 74.28% were resistant to ampicillin, 62.85% were resistant to amoxicillin associated with clavalunate. The mechanism of resistance that presented the highest expression was ESBL (17.14%). The genes studied that were detected in a greater number of species were blaGIM and blaSIM (66.66% of the samples) and the one that was amplified in a smaller number of samples was blaVIM (16.66%). Therefore, high and worrying levels of antimicrobial resistance have been found in enterobacteria, and a way to minimize the accelerated emergence of their resistance includes developing or improving techniques that generate diagnoses with high efficiency and speed. View Full-Text
Keywords: antibiogram; antimicrobial resistance; β-lactams; enterobacterias; molecular diagnosis antibiogram; antimicrobial resistance; β-lactams; enterobacterias; molecular diagnosis
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MDPI and ACS Style

Santos, A.L.; dos Santos, A.P.; Ito, C.R.M.; Queiroz, P.H.P.d.; de Almeida, J.A.; de Carvalho Júnior, M.A.B.; de Oliveira, C.Z.; Avelino, M.A.G.; Wastowski, I.J.; Gomes, G.P.L.A.; Souza, A.C.S.e.; Vasconcelos, L.S.N.d.O.L.; Santos, M.d.O.; da Silva, C.A.; Carneiro, L.C. Profile of Enterobacteria Resistant to Beta-Lactams. Antibiotics 2020, 9, 410.

AMA Style

Santos AL, dos Santos AP, Ito CRM, Queiroz PHPd, de Almeida JA, de Carvalho Júnior MAB, de Oliveira CZ, Avelino MAG, Wastowski IJ, Gomes GPLA, Souza ACSe, Vasconcelos LSNdOL, Santos MdO, da Silva CA, Carneiro LC. Profile of Enterobacteria Resistant to Beta-Lactams. Antibiotics. 2020; 9(7):410.

Chicago/Turabian Style

Santos, Andressa L., Adailton P. dos Santos, Célia R.M. Ito, Pedro H.P.d. Queiroz, Juliana A. de Almeida, Marcos A.B. de Carvalho Júnior, Camila Z. de Oliveira, Melissa A.G. Avelino, Isabela J. Wastowski, Giselle P.L.A. Gomes, Adenícia C.S.e. Souza, Lara S.N.d.O.L. Vasconcelos, Mônica d.O. Santos, Carla A. da Silva, and Lilian C. Carneiro. 2020. "Profile of Enterobacteria Resistant to Beta-Lactams" Antibiotics 9, no. 7: 410.

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