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Article

Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant Staphylococcus aureus Bacteremia

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Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI 48201, USA
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Henry Ford Hospital, Wayne State University School of Medicine, Detroit, MI 48201, USA
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Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA
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Department of Pharmacy, Mount Sinai Hospital, University Health Network, Toronto, ON M5G 1X5, Canada
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Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA
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Sharp Memorial Hospital, San Diego, CA 92093, USA
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Department of Biochemistry, Microbiology and Immunology, Wayne State University College of Medicine, Detroit, MI 48201, USA
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(1), 2; https://doi.org/10.3390/antibiotics9010002
Received: 18 October 2019 / Revised: 22 November 2019 / Accepted: 16 December 2019 / Published: 18 December 2019
(This article belongs to the Special Issue Methicillin-Resistant Staphylococci)
Immune biomarkers can stratify mortality risk in staphylococcal bacteremia. Microbial biomarkers may provide more consistent signals during early infection. We demonstrate that in ST45/USA600 bacteremia, bacterial membrane vesicle production in vitro predicts clinical mortality (773 vs. 116 RFU, survivors vs. decedents, p < 0.0001). Using a threshold of 301 relative fluorescence units (RFU), the sensitivity and specificity of the membrane vesicles to predict mortality are 78% and 90%, respectively. This platform is facile, scalable and can be integrated into clinical microbiology lab workflows. View Full-Text
Keywords: MRSA; membrane vesicles; clinical outcome; biomarker; USA600 MRSA; membrane vesicles; clinical outcome; biomarker; USA600
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MDPI and ACS Style

Dey, S.; Gudipati, S.; Giuliano, C.; Zervos, M.J.; Monk, J.M.; Szubin, R.; Jorgensen, S.C.J.; Sakoulas, G.; Berti, A.D. Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant Staphylococcus aureus Bacteremia. Antibiotics 2020, 9, 2. https://doi.org/10.3390/antibiotics9010002

AMA Style

Dey S, Gudipati S, Giuliano C, Zervos MJ, Monk JM, Szubin R, Jorgensen SCJ, Sakoulas G, Berti AD. Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant Staphylococcus aureus Bacteremia. Antibiotics. 2020; 9(1):2. https://doi.org/10.3390/antibiotics9010002

Chicago/Turabian Style

Dey, Somrita, Smitha Gudipati, Christopher Giuliano, Marcus J. Zervos, Jonathan M. Monk, Richard Szubin, Sarah C. J. Jorgensen, George Sakoulas, and Andrew D. Berti. 2020. "Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant Staphylococcus aureus Bacteremia" Antibiotics 9, no. 1: 2. https://doi.org/10.3390/antibiotics9010002

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