Next Article in Journal
The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action against Salmonella Typhimurium and Staphylococcus aureus
Next Article in Special Issue
The Urgent Need for Novel Antimicrobial Agents and Strategies to Fight Antibiotic Resistance
Previous Article in Journal
Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
Previous Article in Special Issue
In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens
Open AccessCommunication

Novel Small-molecule Antibacterials against Gram-positive Pathogens of Staphylococcus and Enterococcus Species

1
Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany
2
Institute of Molecular Infection Biology, Julius Maximilians University Würzburg, 97080 Würzburg, Germany
3
Institute of Biochemistry, Ernst-Moritz-Arndt-University Greifswald, 17489 Greifswald, Germany
*
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(4), 210; https://doi.org/10.3390/antibiotics8040210
Received: 27 September 2019 / Revised: 22 October 2019 / Accepted: 30 October 2019 / Published: 2 November 2019
Defeat of the antibiotic resistance of pathogenic bacteria is one great challenge today and for the future. In the last century many classes of effective antibacterials have been developed, so that upcoming resistances could be met with novel drugs of various compound classes. Meanwhile, there is a certain lack of research of the pharmaceutical companies, and thus there are missing developments of novel antibiotics. Gram-positive bacteria are the most important cause of clinical infections. The number of novel antibacterials in clinical trials is strongly restricted. There is an urgent need to find novel antibacterials. We used synthetic chemistry to build completely novel hybrid molecules of substituted indoles and benzothiophene. In a simple one-pot reaction, two novel types of thienocarbazoles were yielded. Both indole substituted compound classes have been evaluated as completely novel antibacterials against the Staphylococcus and Enterococcus species. The evaluated partly promising activities depend on the indole substituent type. First lead compounds have been evaluated within in vivo studies. They confirmed the in vitro results for the new classes of small-molecule antibacterials. View Full-Text
Keywords: antibacterial activity; synthesis; substituent; structure-activity; inhibition antibacterial activity; synthesis; substituent; structure-activity; inhibition
Show Figures

Figure 1

MDPI and ACS Style

Seethaler, M.; Hertlein, T.; Wecklein, B.; Ymeraj, A.; Ohlsen, K.; Lalk, M.; Hilgeroth, A. Novel Small-molecule Antibacterials against Gram-positive Pathogens of Staphylococcus and Enterococcus Species. Antibiotics 2019, 8, 210.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop