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Brief Report

A Case of Ertapenem Neurotoxicity Resulting in Vocal Tremor and Altered Mentation in a Dialysis Dependent Liver Transplant Patient

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Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 700 Tiverton Ave., Los Angeles, CA 90095, USA
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Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 700 Tiverton Ave., Los Angeles, CA 90095, USA
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Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 700 Tiverton Ave., Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(1), 1; https://doi.org/10.3390/antibiotics8010001
Received: 27 November 2018 / Revised: 14 December 2018 / Accepted: 18 December 2018 / Published: 22 December 2018
Carbapenem agents are advanced derivatives of cephalosporins that are active against bacteria that produce extended spectrum beta lactamases (ESBL). These antibiotics are resistant to enzymatic cleavage, and have good central nervous system penetration. Given this fact, it is not surprising that these drugs have been reported to cause neurological side effects like seizures and encephalopathy. We report a case of a patient on hemodialytic support who had a notable change in mentation and vocal tremor. This was at first attributed to calcineurin toxicity, but after the finding of a normal tacrolimus level, ertapenem neurotoxicity was suspected. After discontinuation of the offending agent, the patient’s vocal tremor, cognition, and neurological function returned to baseline levels. View Full-Text
Keywords: carbapenem; encephalopathy; vocal tremor; neurotoxicity carbapenem; encephalopathy; vocal tremor; neurotoxicity
MDPI and ACS Style

Hanna, R.M.; Sun, S.-F.; Gaynor, P. A Case of Ertapenem Neurotoxicity Resulting in Vocal Tremor and Altered Mentation in a Dialysis Dependent Liver Transplant Patient. Antibiotics 2019, 8, 1. https://doi.org/10.3390/antibiotics8010001

AMA Style

Hanna RM, Sun S-F, Gaynor P. A Case of Ertapenem Neurotoxicity Resulting in Vocal Tremor and Altered Mentation in a Dialysis Dependent Liver Transplant Patient. Antibiotics. 2019; 8(1):1. https://doi.org/10.3390/antibiotics8010001

Chicago/Turabian Style

Hanna, Ramy M., Shih-Fan Sun, and Pryce Gaynor. 2019. "A Case of Ertapenem Neurotoxicity Resulting in Vocal Tremor and Altered Mentation in a Dialysis Dependent Liver Transplant Patient" Antibiotics 8, no. 1: 1. https://doi.org/10.3390/antibiotics8010001

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