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Case Report

First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

1
Microbiology and Immunology Department, Interdisciplinary Research Centre Egas Moniz (CiiEM), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal
2
Institute of Environmental Health (ISAMB), Faculty of Medicine, Universidade de Lisboa, 1649-028 Lisboa, Portugal
3
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal
4
Faculty of Pharmacy, Universidade de Coimbra, Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
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Laboratory of Microbiology, Centro Hospitalar Lisboa Norte, 1649-035 Lisboa, Portugal
6
Institute of Microbiology, Institute of Molecular Medicine, Faculty of Medicine, Universidade de Lisboa, 1649-028 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
Antibiotics 2018, 7(4), 96; https://doi.org/10.3390/antibiotics7040096
Received: 7 September 2018 / Revised: 29 October 2018 / Accepted: 2 November 2018 / Published: 6 November 2018
(This article belongs to the Special Issue Antimicrobial Resistance in Gram-negative Bacteria)
Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin. View Full-Text
Keywords: antimicrobial resistance; Gram-negative bacteria; K. pneumoniae; A. baumannii; KPC-3 carbapenemase; colistin; tigecycline antimicrobial resistance; Gram-negative bacteria; K. pneumoniae; A. baumannii; KPC-3 carbapenemase; colistin; tigecycline
MDPI and ACS Style

Caneiras, C.; Calisto, F.; Jorge da Silva, G.; Lito, L.; Melo-Cristino, J.; Duarte, A. First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal. Antibiotics 2018, 7, 96. https://doi.org/10.3390/antibiotics7040096

AMA Style

Caneiras C, Calisto F, Jorge da Silva G, Lito L, Melo-Cristino J, Duarte A. First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal. Antibiotics. 2018; 7(4):96. https://doi.org/10.3390/antibiotics7040096

Chicago/Turabian Style

Caneiras, Cátia, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, and Aida Duarte. 2018. "First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal" Antibiotics 7, no. 4: 96. https://doi.org/10.3390/antibiotics7040096

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