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Open AccessCase Report
Antibiotics 2018, 7(4), 109; https://doi.org/10.3390/antibiotics7040109

Emerging Chryseobacterium indologenes Infection in Indian Neonatal Intensive Care Units: A Case Report

1
and
1,2,3,4,*
1
Department of Pediatrics, RD Gardi Medical College, Ujjain 456006, India
2
Department of Women and Children’s Health, International Maternal and Child Health Unit, Uppsala University, SE-751 85 Uppsala, Sweden
3
Department of Public Health Sciences, Global Health—Health Systems and Policy, Karolinska Institutet, SE-171 76 Stockholm, Sweden
4
International Centre for Health Research, Ujjain Charitable Trust Hospital and Research Centre, Ujjain 456006, India
*
Author to whom correspondence should be addressed.
Received: 8 November 2018 / Revised: 5 December 2018 / Accepted: 12 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue Antimicrobial Resistance in Gram-negative Bacteria)
Full-Text   |   PDF [203 KB, uploaded 14 December 2018]

Abstract

Antibiotic-resistant pathogens and nosocomial infections constitute common and serious problems for neonates admitted to neonatal intensive care units worldwide. Chryseobacterium indologenes is a non-lactose-fermenting, gram-negative, health care-associated pathogen (HCAP). It is ubiquitous and intrinsically resistant to several antibiotics. Despite its low virulence, C. indologenes has been widely reported to cause life-threatening infections. Patients on chronic immunosuppressant drugs, harboring invasive devices and indwelling catheters become the nidus for C. indologenes. Typically, C. indologenes causes major health care-associated infections such as pneumonia, empyema, pyelonephritis, cystitis, peritonitis, meningitis, and bacteremia in patients harboring central venous catheters. Management of C. indologenes infection in neonates is not adequately documented owing to underreporting, particularly in India. Because of its multidrug resistance and the scant availability of data from the literature, the effective empirical treatment of C. indologenes is challenging. We present an uncommon case of bacteremia caused by C. indologenes in a preterm newborn baby with moderate respiratory distress syndrome who was successfully treated. We also provide a review of infections in the neonatal age group. Henceforth, in neonates receiving treatments involving invasive equipment use and long-term antibiotic therapy, multidrug resistant C. indologenes should be considered an HCAP. View Full-Text
Keywords: Chryseobacterium indologenes; blood stream infection; newborns; healthcare-associated pathogen Chryseobacterium indologenes; blood stream infection; newborns; healthcare-associated pathogen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mehta, R.; Pathak, A. Emerging Chryseobacterium indologenes Infection in Indian Neonatal Intensive Care Units: A Case Report. Antibiotics 2018, 7, 109.

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