Next Article in Journal
Demographic and Psychological Factors Associated with Feelings of Antibiotic Entitlement in New Zealand
Previous Article in Journal
Plasmon Resonance of Silver Nanoparticles as a Method of Increasing Their Antibacterial Action
Article Menu

Export Article

Open AccessReview
Antibiotics 2018, 7(3), 81; https://doi.org/10.3390/antibiotics7030081

Phenoxymethylpenicillin Versus Amoxicillin for Infections in Ambulatory Care: A Systematic Review

1
Faculty of Medicine, University of Oslo, 0318 Oslo, Norway
2
The Antibiotic Centre for Primary Care, Department of General Practice, Institute of Health and Society, University of Oslo, 0318 Oslo, Norway
*
Author to whom correspondence should be addressed.
Received: 6 July 2018 / Revised: 27 August 2018 / Accepted: 29 August 2018 / Published: 4 September 2018
Full-Text   |   PDF [562 KB, uploaded 4 September 2018]   |  

Abstract

Most antibiotics are prescribed in primary care, and commonly for respiratory tract infections (RTIs). Narrow-spectrum phenoxymethylpenicillin is the antibiotic of choice for RTIs in the Scandinavian countries, while broader spectrum amoxicillin is used in most other European countries. This review summarizes the knowledge of the effect of phenoxymethylpenicillin versus amoxicillin for infections treated in ambulatory care. We searched PubMed/Medline and Embase for trials comparing the clinical effect of phenoxymethylpenicillin and amoxicillin. The Norwegian Knowledge Centre for the Health Services’ checklist was used to assess risk of bias. In total, 1687 studies were identified, and 18 of these fulfilled the inclusion criteria. One additional study was found as a reference. The randomized controlled trials revealed no significant differences in clinical effect in acute sinusitis (three RCTs), GAS tonsillitis (11 RCTs) and Lyme borreliosis (two RCTs). One RCT on community-acquired pneumonia found amoxicillin to be superior, while the results were conflicting in the two RCTs on acute otitis. The results suggest that non-Scandinavian countries should consider phenoxymethylpenicillin as the treatment of choice for RTIs because of its narrower spectrum. More studies should be conducted on the clinical effect of phenoxymethylpenicillin versus amoxicillin for acute otitis and lower RTIs. View Full-Text
Keywords: phenoxymethylpenicillin; amoxicillin; antibiotics; resistance; treatment; ambulatory care; primary health care phenoxymethylpenicillin; amoxicillin; antibiotics; resistance; treatment; ambulatory care; primary health care
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Skarpeid, P.L.; Høye, S. Phenoxymethylpenicillin Versus Amoxicillin for Infections in Ambulatory Care: A Systematic Review. Antibiotics 2018, 7, 81.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top