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Antibiotics 2018, 7(3), 61; https://doi.org/10.3390/antibiotics7030061

Production of β-Lactamase Inhibitors by Streptomyces Species

1
Campus Serra Talhada, University of Pernambuco, Avenida Custódio Conrado, 600, AABB, Serra Talhada, Pernambuco 56912-550, Brazil
2
Department of Antibiotics, Federal University of Pernambuco, Avenida da Engenharia, 2° andar, Cidade Universitária, Recife, Pernambuco 50740-600, Brazil
3
Department of Bioprocesses and Biotechnology, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jaú/Km 01, Araraquara 14800-903, Brazil
4
Campus Garanhuns, University of Pernambuco, Rua Capitão Pedro Rodrigues, 105, São José, Garanhuns, Pernambuco 55295-110, Brazil
5
Department of Civil, Chemical and Environmental Engineering, Chemical Pole, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy
6
Department of Morphology and Animal Physiology, Federal Rural University of Pernambuco, Av. Dom Manoel de Medeiros, Recife, Pernambuco 52171-900, Brazil
*
Author to whom correspondence should be addressed.
Received: 30 May 2018 / Revised: 7 July 2018 / Accepted: 12 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Actinomycetes: The Antibiotics Producers)
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Abstract

β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials and β-lactamase inhibitors such as clavulanic acid, which is largely applied in clinical practice. To protect against the increasing prevalence of multidrug-resistant bacterial strains, new antibiotics and β-lactamase inhibitors need to be discovered and developed. This review will cover an update about the main β-lactamase inhibitors producers belonging to the Streptomyces genus; advanced methods, such as genetic and metabolic engineering, to enhance inhibitor production compared with wild-type strains; and fermentation and purification processes. Moreover, clinical practice and commercial issues are discussed. The commitment of companies and governments to develop innovative strategies and methods to improve the access to new, efficient, and potentially cost-effective microbial products to combat the antimicrobial resistance is also highlighted. View Full-Text
Keywords: actinobacteria; β-lactamase; resistance; antibiotic; β-lactamase inhibitor actinobacteria; β-lactamase; resistance; antibiotic; β-lactamase inhibitor
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Viana Marques, D.A.; Machado, S.E.F.; Ebinuma, V.C.S.; Duarte, C.A.L.; Converti, A.; Porto, A.L.F. Production of β-Lactamase Inhibitors by Streptomyces Species. Antibiotics 2018, 7, 61.

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