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Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria
 
 
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Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections

Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA
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Author to whom correspondence should be addressed.
Present address: National Innovation Foundation, Department of Science and Technology, Government of India, Near Grambharati Circle, Amrapur, Gandhinagar, Gujarat 382721, India
Academic Editor: William M. Shafer
Antibiotics 2015, 4(1), 44-61; https://doi.org/10.3390/antibiotics4010044
Received: 4 October 2014 / Accepted: 23 December 2014 / Published: 12 January 2015
(This article belongs to the Special Issue Antimicrobial Peptides)
The emergence of antibiotic resistance seriously threatens our ability to treat many common and medically important bacterial infections. Novel therapeutics are needed that can be used alone or in conjunction with antibiotics. Cationic antimicrobial peptides (CAMPs) are important effectors of the host innate defense that exhibit broad-spectrum activity against a wide range of microorganisms. CAMPs are carried within phagocytic granules and are constitutively or inducibly expressed by multiple cell types, including epithelial cells. The role of histone modification enzymes, specifically the histone deacetylases (HDAC), in down-regulating the transcription of CAMP-encoding genes is increasingly appreciated as is the capacity of HDAC inhibitors (HDACi) to block the action of HDACs to increase CAMP expression. The use of synthetic and natural HDACi molecules to increase CAMPs on mucosal surfaces, therefore, has potential therapeutic applications. Here, we review host and pathogen regulation of CAMP expression through the induction of HDACs and assess the therapeutic potential of natural and synthetic HDACi based on evidence from tissue culture systems, animal models, and clinical trials. View Full-Text
Keywords: chromatin remodeling; histone deacetylase inhibitors; antimicrobial peptides; bacterial infections; anti-infectives chromatin remodeling; histone deacetylase inhibitors; antimicrobial peptides; bacterial infections; anti-infectives
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MDPI and ACS Style

Yedery, R.D.; Jerse, A.E. Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections. Antibiotics 2015, 4, 44-61. https://doi.org/10.3390/antibiotics4010044

AMA Style

Yedery RD, Jerse AE. Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections. Antibiotics. 2015; 4(1):44-61. https://doi.org/10.3390/antibiotics4010044

Chicago/Turabian Style

Yedery, Roshan D., and Ann E. Jerse. 2015. "Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections" Antibiotics 4, no. 1: 44-61. https://doi.org/10.3390/antibiotics4010044

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