Error in Table 2
In the original publication [1], there was a mistake in Table 2, published as follows: Patients 1 and 23 presented clinical failure at day 14, as reported in the text. In addition, by error patient 23 should also appear as mortality at day 30: Yes, and patient 24 mortality at day 30 should be No.
The corrected version of Table 2 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Table 2.
Demographic, clinical, and outcome characteristics of the 34 patients with infections caused by VIM-type-producing Gram-negative bacteria treated with cefiderocol.
Table 2.
Demographic, clinical, and outcome characteristics of the 34 patients with infections caused by VIM-type-producing Gram-negative bacteria treated with cefiderocol.
| Patient | Age, yr (Sex) | Underlying Disease | CCI | Type of Infection | Bacterial Species | Bacteremia | Drainable Source/Drainage Performed | Additional Therapy | Days of Treatment | Clinical Failure at Day 14 | Mortality at Day 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 82 (M) | Renal transplant recipient | 7 | Primary bacteremia | P. aeruginosa | Yes | No | No | 8 | Yes | Yes |
| 2 | 89 (M) | Chronic ischemia right lower limb | 14 | Chronic osteomyelitis | E. cloacae | No | Yes/Yes: Limb amputation | No | 13 | No | Yes |
| 3 | 63 (M) | Lung transplant recipient | 2 | Previous ECMO cannula wound infection | Raoultella ornithinolytica, E. coli | No | Yes/Yes: Resection of the infected wound | No | 13 | No | No |
| 4 | 76 (F) | Diverticulitis | 4 | Postoperative deep wound infection | Achromobacter sp., P. aeruginosa | No | Yes/No: Undrained abscess | No | 8 | No | No |
| 5 | 56 (M) | COVID-19 pneumonia | 3 | Primary bacteremia and ECMO cannula infection | Achromobacter sp. | Yes | Yes/No: ECMO cannula not retired | Intravenous colistin (after 22 days of cefiderocol) | 27 | Yes | Yes |
| 6 | 39 (M) | COVID-19 pneumonia in a lung transplant recipient | 1 | ECMO cannula wound infection + tracheobronchitis | P. aeruginosa | No | Yes/No: ECMO cannula not retired | Nebulized colistin | 6 | Yes | Yes |
| 7 | 51 (M) | Acute pancreatitis | 2 | Catheter-associated urinary infection | Achromobacter sp. | No | No | No | 11 | No | Yes |
| 8 | 78 (F) | Renal transplant recipient | 10 | Femoro-femoral bypass graft infection | E. cloacae | No | Yes/No: By-pass not explanted | No | 13 | No | No |
| 9 | 65 (M) | Renal transplant recipient | 6 | Obstructive pyelonephritis | E. cloacae, P. aeruginosa | Yes | Yes/Yes: Ureteral stent placement | No | 27 | No | No |
| 10 | 59 (M) | Acute myeloid leukemia and recent allo-HSCT | 3 | Tonsillar abscess | P. aeruginosa | Yes | Yes/No: Undrained abscess | Intravenous amikacin (during the first 3 days) | 22 | Yes | Yes |
| 11 | 41 (M) | NK/T-cell lymphoma | 2 | Infected pancreatic necrosis | P. aeruginosa | No | Yes/Yes: Abscess drainage | No | 62 | No | No |
| 12 | 56 (F) | Follicular lymphoma with persistent COVID-19 | 2 | Catheter-associated UTI | Achromobacter sp. | No | No | No | 5 | No | No |
| 13 | 67 (M) | Lung transplant recipient | 2 | Acute tracheobronchitis | P. aeruginosa | No | No | Nebulized colistin | 7 | No | No |
| 14 | 77 (F) | Acute myeloid leukemia | 5 | Soft tissue infection | P. aeruginosa | No | No | No | 14 | No | No |
| 15 | 61 (M) | Hemorrhagic shock | 7 | Catheter-associated UTI | Achromobacter sp. | No | No | No | 7 | No | Yes |
| 16 | 56 (M) | Tibial osteomyelitis | 0 | Chronic osteomyelitis | P. putida | No | Yes/Yes: Osteomyelitis debridement | No | 14 | No | No |
| 17 | 70 (M) | COPD | 5 | Nosocomial pneumonia | P. aeruginosa | Yes | No | No | 25 | No | Yes |
| 18 | 51 (M) | Renal transplant recipient | 3 | Renal graft pyelonephritis | P. aeruginosa | No | No | No | 17 | No | No |
| 19 | 54 (M) | Elbow osteomyelitis | 1 | Osteosynthesis-associated infection | E. cloacae | No | Yes/Yes: Osteosynthesis implant removal | No | 32 | No | No |
| 20 | 58 (M) | Renal transplant recipient | 4 | Postoperative deep wound infection | P. aeruginosa | No | Yes/No: Undrained abscess | No | 28 | No | No |
| 21 | 67 (M) | Lung transplant recipient | 4 | Acute tracheobronchitis | P. aeruginosa | Yes | No | Nebulized colistin | 15 | No | No |
| 22 | 54 (F) | Lung transplant recipient | 3 | Acute tracheobronchitis | Enterobacter hormaechei | No | No | Nebulized amikacin | 6 | No | No |
| 23 | 45 (M) | Richter’s Syndrome | 2 | Intestinal bacterial translocation | P. aeruginosa | Yes | No | No | 9 | Yes | Yes |
| 24 | 53 (F) | Open tibia fracture | 1 | Tibial osteomyelitis | P. aeruginosa | No | Yes/Yes: Osteomyelitis debridement | No | 38 | No | No |
| 25 | 54 (F) | Metastatic kidney cancer | 5 | Catheter-related bloodstream infection | P. aeruginosa | Yes | Yes/Yes: Catheter removal | No | 5 | No | No |
| 26 | 78 (F) | Renal transplant recipient | 9 | Postoperative deep wound infection | P. putida | No | Yes/Yes: Abscess drainage | No | 41 | No | No |
| 27 | 44 (F) | Renal transplant recipient | 3 | Postoperative deep wound infection | P. putida | No | Yes/No: Undrained abscess | No | 12 | No | No |
| 28 | 49 (M) | Lung transplant recipient | 4 | Acute tracheobronchitis | P. aeruginosa | No | No | No | 14 | No | No |
| 29 | 75 (M) | Status epilepticus | 3 | Ventilator-associated pneumonia | P. aeruginosa | No | No | Nebulized colistin | 9 | No | No |
| 30 | 77 (M) | Multiple organ dysfunction syndrome | 8 | Acute tracheobronchitis | P. aeruginosa | No | No | No | 10 | No | No |
| 31 | 59 (F) | Pulmonary fibrosis | 1 | Acute tracheobronchitis | P. aeruginosa | No | No | Nebulized colistin | 8 | No | No |
| 32 | 80 (M) | Meige syndrome (tracheostomy) | 4 | Acute tracheobronchitis | P. aeruginosa | No | No | Nebulized aztreonam | 10 | No | No |
| 33 | 56 (M) | Acute lymphoblastic leukemia | 4 | Prostatic abscess | P. aeruginosa | No | Yes/No: Undrained abscess | No | 33 | No | No |
| 34 | 63 (M) | Renal transplant recipient | 5 | Renal graft pyelonephritis | P. putida | No | No | No | 18 | No | No |
Abbreviations: allo-HSCT, allogeneic hematopoietic stem cell transplantation; CCI, Charlson comorbidity index; ECMO, extracorporeal membrane oxygenation; F, female; M, male; UTI, urinary tract infection; and COPD, chronic obstructive pulmonary disease.
Reference
- Kirkegaard-Biosca, C.; del Barrio-Tofiño, E.; Villamarín, M.; Larrosa, N.; Campany, D.; González-López, J.J.; Ferrer, R.; Viñado, B.; Doménech, L.; Sellarès-Nadal, J.; et al. Cefiderocol for the Treatment of Infections by VIM-Type-Producing Gram-Negative Bacteria. Antibiotics 2024, 13, 874. [Google Scholar] [CrossRef] [PubMed]
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