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Volume 12
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Review

Current and Future Pathways in Aspergillus Diagnosis

by
Radim Dobiáš
1,2,
David A. Stevens
3,4,* and
Vladimír Havlíček
5,6
1
Department of Bacteriology and Mycology, Public Health Institute in Ostrava, Partyzánské Náměstí 2633/7, 702 00 Ostrava, Czech Republic
2
Institute of Laboratory Medicine, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic
3
California Institute for Medical Research, 2260 Clove Drive, San Jose, CA 95128, USA
4
Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA 95128, USA
5
Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic
6
Department of Analytical Chemistry, Faculty of Science, Palacký University, 17. Listopadu 12, 771 46 Olomouc, Czech Republic
*
Author to whom correspondence should be addressed.
Antibiotics 2023, 12(2), 385; https://doi.org/10.3390/antibiotics12020385
Submission received: 20 December 2022 / Revised: 10 February 2023 / Accepted: 10 February 2023 / Published: 13 February 2023
(This article belongs to the Section Fungi and Their Metabolites)
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Abstract

Aspergillus fumigatus has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and extracellular secretomes. This review summarizes the shortcomings of antibody tests compared to tests of fungal products in body fluids and highlights the application of β-d-glucan, galactomannan, and pentraxin 3 in bronchoalveolar lavage fluids. We also discuss the detection of nucleic acids and next-generation sequencing, along with newer studies on Aspergillus metallophores.
Keywords: aspergillosis; galactomannan; β-d-glucan; PCR; metagenomic next-generation sequencing; lateral flow; bronchoalveolar lavage fluid; serum assays; siderophore; metallophore aspergillosis; galactomannan; β-d-glucan; PCR; metagenomic next-generation sequencing; lateral flow; bronchoalveolar lavage fluid; serum assays; siderophore; metallophore

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MDPI and ACS Style

Dobiáš, R.; Stevens, D.A.; Havlíček, V. Current and Future Pathways in Aspergillus Diagnosis. Antibiotics 2023, 12, 385. https://doi.org/10.3390/antibiotics12020385

AMA Style

Dobiáš R, Stevens DA, Havlíček V. Current and Future Pathways in Aspergillus Diagnosis. Antibiotics. 2023; 12(2):385. https://doi.org/10.3390/antibiotics12020385

Chicago/Turabian Style

Dobiáš, Radim, David A. Stevens, and Vladimír Havlíček. 2023. "Current and Future Pathways in Aspergillus Diagnosis" Antibiotics 12, no. 2: 385. https://doi.org/10.3390/antibiotics12020385

APA Style

Dobiáš, R., Stevens, D. A., & Havlíček, V. (2023). Current and Future Pathways in Aspergillus Diagnosis. Antibiotics, 12(2), 385. https://doi.org/10.3390/antibiotics12020385

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