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Antibiotics
Volume 12
Issue 1
10.3390/antibiotics12010086
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Article
Peer-Review Record

Clostridioides difficile in South American Camelids in Germany: First Insights into Molecular and Genetic Characteristics and Antimicrobial Resistance

Antibiotics 2023, 12(1), 86; https://doi.org/10.3390/antibiotics12010086
by Ines Dost 1,*, Mostafa Abdel-Glil 1, Gernot Schmoock 1, Christian Menge 2, Christian Berens 2, Belén González-Santamarina 2,†, Elisabeth Wiegand 2,‡, Heinrich Neubauer 1, Stefan Schwarz 3,4 and Christian Seyboldt 1
Reviewer 1:
Shizhou Wu
Reviewer 2:
Arun Kharat
Antibiotics 2023, 12(1), 86; https://doi.org/10.3390/antibiotics12010086
Submission received: 1 December 2022 / Revised: 22 December 2022 / Accepted: 23 December 2022 / Published: 4 January 2023

Round 1

Reviewer 1 Report

Clostridioides (C.) difficile as an enteric pathogen can cause zoonotic transmission. This study investigates the prevalence, molecular characteristics and antimicrobial resistances of C. difficile in South American camelid (SAC) with increasing popularity and frequent contacting with humans.

 

As authors mentioned “All isolates were obtained only from enrichment cultures and belonged to five different PCR ribotypes (RT):” Could the different characteristics among those RTs be briefly described?

 

The samples of this text are very limited. Could authors do a mini review about others associated research which make your findings more stable?

 

This text did the analysis of single nucleotide polymorphisms (SNPs). But the meaning of this results needs to be explained simultaneously.

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Authors have addressed an important topic and is of a general interest in present time. Experiments are well designed as well as appropriately executed. Just a minor comments, author should address to improve MS furthter

1.  Authors need to recheck presentation of Table 5, especially attributing status as to Sensitive, Intermediate and Resistant as per EUCAST/CLSI.  They must ensure color coding is exactly matching.  

2. Choice of traits do not look in the light of Extended Spectrum beta-lactamases classification by Ambler.  Although its not must, however it would be better if authors can explain in brief rationale of choosing certain bla traits and not classifying isolated as per Ambler.

Best

Arun

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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