Next Article in Journal
Azithromycin: An Underappreciated Quinolone-Sparing Oral Treatment for Pseudomonas aeruginosa Infections
Next Article in Special Issue
Genomic Diversity of NDM-Producing Klebsiella Species from Brazil, 2013–2022
Previous Article in Journal
Secondary Metabolite Variation and Bioactivities of Two Marine Aspergillus Strains in Static Co-Culture Investigated by Molecular Network Analysis and Multiple Database Mining Based on LC-PDA-MS/MS
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antibiotics
Volume 11
Issue 4
10.3390/antibiotics11040514
antibiotics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Communication

Multicenter Study of Carbapenemase-Producing Enterobacterales in Havana, Cuba, 2016–2021

by
Haiyang Yu
1,
María Karla González Molina
1,
Yenisel Carmona Cartaya
1,
Marcia Hart Casares
2,
Meiji Soe Aung
3,
Nobumichi Kobayashi
3,* and
Dianelys Quiñones Pérez
1,*
1
Healthcare-Associated Infections National Laboratory, Pedro Kourí Institute of Tropical Medicine, Havana 11400, Cuba
2
Microbiology Laboratory, Hermanos Ameijeiras Hospital, Havana 10400, Cuba
3
Department of Hygiene, Sapporo Medical University, Sapporo 060-8556, Japan
*
Authors to whom correspondence should be addressed.
Antibiotics 2022, 11(4), 514; https://doi.org/10.3390/antibiotics11040514
Submission received: 22 March 2022 / Revised: 1 April 2022 / Accepted: 6 April 2022 / Published: 12 April 2022
(This article belongs to the Special Issue Carbapenem-Resistant Enterobacterales)
Browse Figures
Versions Notes

Abstract

Surveillance of carbapenem resistance is particularly important for Enterobacterales, mainly in countries with limited healthcare resources. We conducted a cross-sectional study to detect carbapenem-resistant Enterobacterales at 10 sentinel hospitals in Havana, Cuba for a six year-period (2016–2021) by the National Reference Laboratory for Health Care-Associated Infections in the Pedro Kourí Institute. A total of 152 isolates were collected with phenotypic production of metallo-β-lactamase. NDM-type carbapenemase was detected in all the 152 isolates, and KPC-type enzyme gene was simultaneously identified in four NDM-positive isolates. The most abundant carbapenemase-producing Enterobacterales (CPE) species was Klebsiella pneumoniae (69.7%), followed by Enterobacter cloacae complex (13.2%), and Escherichia coli (5.9%). Over the study period, among CPE, prevalence of K. pneumoniae was almost constant, while Enterobacter spp. showed slightly increasing tendency. The urinary tract (36.2%) was the most prevalent source of infection with CPE, followed by bloodstream (26.3%) and surgical wound (17.1%), being frequently derived from Intensive Care Units (35.5%) and urology wards (21.7%). This study revealed the present situation of CPE in hospitals in Havana, Cuba, showing the emergence and dissemination of Enterobacterales producing NDM-type carbapenemase, mainly K. pneumoniae.
Keywords: carbapenemase; Enterobacterales; Cuba; NDM; Klebsiella pneumoniae; Enterobacter spp. carbapenemase; Enterobacterales; Cuba; NDM; Klebsiella pneumoniae; Enterobacter spp.

Share and Cite

MDPI and ACS Style

Yu, H.; González Molina, M.K.; Carmona Cartaya, Y.; Hart Casares, M.; Aung, M.S.; Kobayashi, N.; Quiñones Pérez, D. Multicenter Study of Carbapenemase-Producing Enterobacterales in Havana, Cuba, 2016–2021. Antibiotics 2022, 11, 514. https://doi.org/10.3390/antibiotics11040514

AMA Style

Yu H, González Molina MK, Carmona Cartaya Y, Hart Casares M, Aung MS, Kobayashi N, Quiñones Pérez D. Multicenter Study of Carbapenemase-Producing Enterobacterales in Havana, Cuba, 2016–2021. Antibiotics. 2022; 11(4):514. https://doi.org/10.3390/antibiotics11040514

Chicago/Turabian Style

Yu, Haiyang, María Karla González Molina, Yenisel Carmona Cartaya, Marcia Hart Casares, Meiji Soe Aung, Nobumichi Kobayashi, and Dianelys Quiñones Pérez. 2022. "Multicenter Study of Carbapenemase-Producing Enterobacterales in Havana, Cuba, 2016–2021" Antibiotics 11, no. 4: 514. https://doi.org/10.3390/antibiotics11040514

APA Style

Yu, H., González Molina, M. K., Carmona Cartaya, Y., Hart Casares, M., Aung, M. S., Kobayashi, N., & Quiñones Pérez, D. (2022). Multicenter Study of Carbapenemase-Producing Enterobacterales in Havana, Cuba, 2016–2021. Antibiotics, 11(4), 514. https://doi.org/10.3390/antibiotics11040514

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop