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Antibiotics
Volume 10
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10.3390/antibiotics10080902
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Article

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

by
Cynthia Amaning Danquah
1,*,
Michael Tetteh
1,
Isaac Kingsley Amponsah
2,
Abraham Yeboah Mensah
2,
Kwame Ohene Buabeng
3,
Simon Gibbons
4 and
Sanjib Bhakta
5
1
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), PMB, Kumasi, Ghana
2
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, PMB, Kumasi, Ghana
3
Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, PMB, Kumasi, Ghana
4
Norwich Research Park, School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK
5
Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
*
Author to whom correspondence should be addressed.
Antibiotics 2021, 10(8), 902; https://doi.org/10.3390/antibiotics10080902
Submission received: 17 June 2021 / Revised: 12 July 2021 / Accepted: 15 July 2021 / Published: 23 July 2021
(This article belongs to the Special Issue 10th Anniversary of Antibiotics - Recent Advances in Antibiotic Biosynthesis)
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Abstract

The bulbs of Allium species are a known source of antibacterial phytochemicals. Anti-infective, efflux pump and biofilm inhibitory activities of bulb extracts of selected Ghanaian shallots Allium cepa var aggregatum were evaluated using the HT-SPOTi assay and other whole-cell phenotypic screening techniques to determine their possible mechanisms of action. Ethanol and aqueous extracts of white A. cepa inhibited the growth of Mycobacterium smegmatis mc2 155 and Escherichia coli, respectively. The majority of the Allium extracts significantly (p < 0.05) exhibited efflux pump inhibitory activity against all the acid-fast, Gram-positive and Gram-negative strains used. Hexane and chloroform extract of the pink A. cepa and the aqueous extract of the white A. cepa significantly inhibited M. smegmatis biofilm formation. For Pseudomonas aeruginosa, the inhibition was observed at 250 µg/mL for the aqueous extract (~77.34%) and 125 µg/mL for the hexane extract (~76.51%). The results suggest that Ghanaian shallots could potentially be useful when further developed to tackle antimicrobial resistance, particularly in tuberculosis (TB).
Keywords: tuberculosis; HT-SPOTi; efflux pumps; biofilms; antimicrobial resistance tuberculosis; HT-SPOTi; efflux pumps; biofilms; antimicrobial resistance

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MDPI and ACS Style

Danquah, C.A.; Tetteh, M.; Amponsah, I.K.; Mensah, A.Y.; Buabeng, K.O.; Gibbons, S.; Bhakta, S. Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis. Antibiotics 2021, 10, 902. https://doi.org/10.3390/antibiotics10080902

AMA Style

Danquah CA, Tetteh M, Amponsah IK, Mensah AY, Buabeng KO, Gibbons S, Bhakta S. Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis. Antibiotics. 2021; 10(8):902. https://doi.org/10.3390/antibiotics10080902

Chicago/Turabian Style

Danquah, Cynthia Amaning, Michael Tetteh, Isaac Kingsley Amponsah, Abraham Yeboah Mensah, Kwame Ohene Buabeng, Simon Gibbons, and Sanjib Bhakta. 2021. "Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis" Antibiotics 10, no. 8: 902. https://doi.org/10.3390/antibiotics10080902

APA Style

Danquah, C. A., Tetteh, M., Amponsah, I. K., Mensah, A. Y., Buabeng, K. O., Gibbons, S., & Bhakta, S. (2021). Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis. Antibiotics, 10(8), 902. https://doi.org/10.3390/antibiotics10080902

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