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Article

Strong Antimicrobial and Healing Effects of Beta-Acids from Hops in Methicillin-Resistant Staphylococcus aureus-Infected External Wounds In Vivo

1
Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic
2
Thomayer Hospital, 110 00 Prague, Czech Republic
3
Research Institute of Brewing and Malting, 110 00 Prague, Czech Republic
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Food Research Institute, 110 00 Prague, Czech Republic
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Hop Research Institute, 438 01 Zatec, Czech Republic
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Department of Microbiology, Faculty of Medicine and Dentistry, University Hospital, Palacky University, 771 47 Olomouc, Czech Republic
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Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic
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Institute of Clinical Microbiology, Faculty of Medicine in Hradec Kralove, Charles University and University Hospital, 500 05 Hradec Kralove, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Maresca
Antibiotics 2021, 10(6), 708; https://doi.org/10.3390/antibiotics10060708
Received: 14 May 2021 / Revised: 4 June 2021 / Accepted: 10 June 2021 / Published: 12 June 2021
Staphylococcus (S.) aureus is an important causative agent of wound infections with increasing incidence in the past decades. Specifically, the emergence of methicillin-resistant S. aureus (MRSA) causes serious problems, especially in nosocomial infections. Therefore, there is an urgent need to develop of alternative or supportive antimicrobial therapeutic modalities to meet these challenges. Purified compounds from hops have previously shown promising antimicrobial effects against MRSA isolates in vitro. In this study, purified beta-acids from hops were tested for their potential antimicrobial and healing properties using a porcine model of wounds infected by MRSA. The results show highly significant antimicrobial effects of the active substance in both the powder and Ambiderman-based application forms compared to both no-treatment control and treatment with Framycoin. Moreover, the macroscopic evaluation of the wounds during the treatment using the standardized Wound Healing Continuum indicated positive effects of the beta-acids on the overall wound healing. This is further supported by the microscopic data, which showed a clear improvement of the inflammatory parameters in the wounds treated by beta-acids. Thus, using the porcine model, we demonstrate significant therapeutic effects of hops compounds in the management of wounds infected by MRSA. Beta-acids from hops, therefore, represent a suitable candidate for the treatment of non-responsive nosocomial tissue infections by MRSA. View Full-Text
Keywords: hops; methicillin-resistant; Staphylococcus aureus; infection; porcine model hops; methicillin-resistant; Staphylococcus aureus; infection; porcine model
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MDPI and ACS Style

Sleha, R.; Radochova, V.; Malis, J.; Mikyska, A.; Houska, M.; Krofta, K.; Bogdanova, K.; Janovska, S.; Pejchal, J.; Kolar, M.; Cermak, P.; Bostik, P. Strong Antimicrobial and Healing Effects of Beta-Acids from Hops in Methicillin-Resistant Staphylococcus aureus-Infected External Wounds In Vivo. Antibiotics 2021, 10, 708. https://doi.org/10.3390/antibiotics10060708

AMA Style

Sleha R, Radochova V, Malis J, Mikyska A, Houska M, Krofta K, Bogdanova K, Janovska S, Pejchal J, Kolar M, Cermak P, Bostik P. Strong Antimicrobial and Healing Effects of Beta-Acids from Hops in Methicillin-Resistant Staphylococcus aureus-Infected External Wounds In Vivo. Antibiotics. 2021; 10(6):708. https://doi.org/10.3390/antibiotics10060708

Chicago/Turabian Style

Sleha, Radek, Vera Radochova, Jiri Malis, Alexander Mikyska, Milan Houska, Karel Krofta, Katerina Bogdanova, Sylva Janovska, Jaroslav Pejchal, Milan Kolar, Pavel Cermak, and Pavel Bostik. 2021. "Strong Antimicrobial and Healing Effects of Beta-Acids from Hops in Methicillin-Resistant Staphylococcus aureus-Infected External Wounds In Vivo" Antibiotics 10, no. 6: 708. https://doi.org/10.3390/antibiotics10060708

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