The Influence of Cellulose-Type Formulants on Anti-Candida Activity of the Tyrocidines
BIOPEPTM Peptide Group, Department Biochemistry, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch 7602, South Africa
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Academic Editors: Giovanna Batoni, Giuseppantonio Maisetta and Semih Esin
Antibiotics 2021, 10(5), 597; https://doi.org/10.3390/antibiotics10050597
Received: 18 March 2021
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Revised: 18 April 2021
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Accepted: 21 April 2021
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Published: 18 May 2021
(This article belongs to the Special Issue Therapeutic Use of Antimicrobial Peptides: Joys and Sorrows)
Candida species are highly adaptable to environmental changes with their phenotypic flexibility allowing for the evasion of most host defence mechanisms. Moreover, increasing resistance of human pathogenic Candida strains has been reported against all four classes of available antifungal drugs, which highlights the need for combinational therapies. Tyrocidines are cyclic antimicrobial peptides that have shown synergistic activity with antifungal drugs such as caspofungin and amphotericin B. However, these cyclodecapeptides have haemolytic activity and cytotoxicity, but they have been used for decades in the clinic for topical applications. The tyrocidines tend to form higher-order structures in aqueous solutions and excessive aggregation can result in variable or diminished activity. Previous studies have shown that the tyrocidines prefer ordered association to celluloses. Therefore, a formulation with soluble cellulose was used to control the oligomer stability and size, thereby increasing the activity against Candida spp. Of the formulants tested, it was found that commercial hydroxy-propyl-methyl cellulose, E10M, yielded the best results with increased stability, increased anti-Candida activity, and improved selectivity. This formulation holds promise in topical applications against Candida spp. infections.
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Keywords:
antimicrobial peptide; cyclic peptide; tyrocidine; Candida albicans; formulation; cellulose
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MDPI and ACS Style
Masoudi, Y.; van Rensburg, W.; Barnard-Jenkins, B.; Rautenbach, M. The Influence of Cellulose-Type Formulants on Anti-Candida Activity of the Tyrocidines. Antibiotics 2021, 10, 597. https://doi.org/10.3390/antibiotics10050597
AMA Style
Masoudi Y, van Rensburg W, Barnard-Jenkins B, Rautenbach M. The Influence of Cellulose-Type Formulants on Anti-Candida Activity of the Tyrocidines. Antibiotics. 2021; 10(5):597. https://doi.org/10.3390/antibiotics10050597
Chicago/Turabian StyleMasoudi, Yasamin, Wilma van Rensburg, Bernice Barnard-Jenkins, and Marina Rautenbach. 2021. "The Influence of Cellulose-Type Formulants on Anti-Candida Activity of the Tyrocidines" Antibiotics 10, no. 5: 597. https://doi.org/10.3390/antibiotics10050597
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