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Antibiotics
Volume 10
Issue 2
10.3390/antibiotics10020096
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Open AccessCommunication

The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus

by
Md Saruar Bhuiyan
1,†,
Jhih-Hang Jiang
1,†,
Xenia Kostoulias
1,
Ravali Theegala
1,
Graham J. Lieschke
2 and
Anton Y. Peleg
1,3,*
1
Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, Australia
2
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia
3
Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC 3004, Australia
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editors: Barbara Skerlavaj and Jean-Marc Sabatier
Antibiotics 2021, 10(2), 96; https://doi.org/10.3390/antibiotics10020096
Received: 10 December 2020 / Revised: 18 January 2021 / Accepted: 18 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue Adaptive Evolution of Bacterial Pathogens in Response to Antibiotic Therapy)
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Abstract

Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen. View Full-Text
Keywords: S. aureus; daptomycin; antimicrobial peptides; persistent infection S. aureus; daptomycin; antimicrobial peptides; persistent infection
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MDPI and ACS Style

Bhuiyan, M.S.; Jiang, J.-H.; Kostoulias, X.; Theegala, R.; Lieschke, G.J.; Peleg, A.Y. The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus. Antibiotics 2021, 10, 96. https://doi.org/10.3390/antibiotics10020096

AMA Style

Bhuiyan MS, Jiang J-H, Kostoulias X, Theegala R, Lieschke GJ, Peleg AY. The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus. Antibiotics. 2021; 10(2):96. https://doi.org/10.3390/antibiotics10020096

Chicago/Turabian Style

Bhuiyan, Md S.; Jiang, Jhih-Hang; Kostoulias, Xenia; Theegala, Ravali; Lieschke, Graham J.; Peleg, Anton Y. 2021. "The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus" Antibiotics 10, no. 2: 96. https://doi.org/10.3390/antibiotics10020096

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