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Article

Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis

1
Amicoat AS, Sykehusvegen 23, 9019 Tromsø, Norway
2
Department of Chemistry, Faculty of Science and Technology, UiT—The Arctic University of Norway, 9037 Tromsø, Norway
3
Department of Medical Biology, Faculty of Health Sciences, UiT—The Arctic University of Norway, 9037 Tromsø, Norway
4
RISE Research Institutes of Sweden, Brinellgatan 4, 504 62 Borås, Sweden
*
Author to whom correspondence should be addressed.
Academic Editors: Marc Maresca, Catherine Lefay and Vincent Humblot
Antibiotics 2021, 10(12), 1516; https://doi.org/10.3390/antibiotics10121516
Received: 28 November 2021 / Revised: 7 December 2021 / Accepted: 8 December 2021 / Published: 10 December 2021
(This article belongs to the Special Issue Antimicrobial Materials and Surface)
Medical devices with an effective anti-colonization surface are important tools for combatting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization. View Full-Text
Keywords: antimicrobial surface; antimicrobial peptide; self-assembled monolayer; antifouling; anti-colonization; ToF-SIMS imaging; Certika antimicrobial surface; antimicrobial peptide; self-assembled monolayer; antifouling; anti-colonization; ToF-SIMS imaging; Certika
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MDPI and ACS Style

Karlsen, E.A.; Stensen, W.; Juskewitz, E.; Svenson, J.; Berglin, M.; Svendsen, J.S.M. Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis. Antibiotics 2021, 10, 1516. https://doi.org/10.3390/antibiotics10121516

AMA Style

Karlsen EA, Stensen W, Juskewitz E, Svenson J, Berglin M, Svendsen JSM. Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis. Antibiotics. 2021; 10(12):1516. https://doi.org/10.3390/antibiotics10121516

Chicago/Turabian Style

Karlsen, Eskil A., Wenche Stensen, Eric Juskewitz, Johan Svenson, Mattias Berglin, and John S.M. Svendsen. 2021. "Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis" Antibiotics 10, no. 12: 1516. https://doi.org/10.3390/antibiotics10121516

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