Nifedipine Potentiates Susceptibility of Salmonella Typhimurium to Different Classes of Antibiotics
Abstract
:1. Introduction
2. Results
2.1. Additive Effect of Different Antibiotics and the Calcium Channel Inhibitor Nifedipine
2.2. Dose-Response Curve of Azithromycin and Nifedipine
2.3. Nifedipine Has No Direct Antibacterial Activity
2.4. Effect of Hepcidin on Antibacterial Activity of Nifedipine against Intramacrophage Salmonella and Mutant Salmonella with Iron Acquisition Defects
2.5. Modulation of Iron Homeostasis by Nifedipine in Infected Macrophages
3. Discussion
4. Materials and Methods
4.1. Cell Culture
4.2. Bacterial Strain and Salmonella Infection of Macrophages
4.3. Western Blot
4.4. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Haschka, D.; Grander, M.; Eibensteiner, J.; Dichtl, S.; Koppelstätter, S.; Weiss, G. Nifedipine Potentiates Susceptibility of Salmonella Typhimurium to Different Classes of Antibiotics. Antibiotics 2021, 10, 1200. https://doi.org/10.3390/antibiotics10101200
Haschka D, Grander M, Eibensteiner J, Dichtl S, Koppelstätter S, Weiss G. Nifedipine Potentiates Susceptibility of Salmonella Typhimurium to Different Classes of Antibiotics. Antibiotics. 2021; 10(10):1200. https://doi.org/10.3390/antibiotics10101200
Chicago/Turabian StyleHaschka, David, Manuel Grander, Johannes Eibensteiner, Stefanie Dichtl, Sabine Koppelstätter, and Günter Weiss. 2021. "Nifedipine Potentiates Susceptibility of Salmonella Typhimurium to Different Classes of Antibiotics" Antibiotics 10, no. 10: 1200. https://doi.org/10.3390/antibiotics10101200