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Biosensors 2018, 8(1), 12;

Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film

Department of Physics, Faculty of Sciences and Technology, UIN Syarif Hidayatullah Jakarta, Tangerang Selatan, Banten 15412, Indonesia
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang 25131, Indonesia
Author to whom correspondence should be addressed.
Received: 10 November 2017 / Revised: 24 January 2018 / Accepted: 24 January 2018 / Published: 30 January 2018
(This article belongs to the Special Issue Continuous Glucose Monitoring)
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A polyvinylidene fluoride (PVDF) film-based capacitive biosensor was developed for glucose sensing. This device consists of a PVDF film sandwiched between two electrodes. A capacitive biosensor measures the dielectric properties of the dielectric layers at the interface between the electrolyte and the electrode. A glucose oxidase (GOx) enzyme was immobilized onto the electrode to oxidize glucose. In practice, the biochemical reaction of glucose with the GOx enzyme generates free electron carriers. Consequently, the potential difference between the electrodes is increased, resulting in a measurable voltage output of the biosensor. The device was tested for various glucose concentrations in the range of 0.013 to 5.85 M, and various GOx enzyme concentrations between 4882.8 and 2.5 million units/L. We found that the sensor output increased with increasing glucose concentration up to 5.85 M. These results indicate that the PVDF film-based capacitive biosensors can be properly applied to glucose sensing and provide opportunities for the low-cost fabrication of glucose-based biosensors based on PVDF materials. View Full-Text
Keywords: capacitive biosensor; glucose sensing; GOx enzyme; PVDF film capacitive biosensor; glucose sensing; GOx enzyme; PVDF film

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Hartono, A.; Sanjaya, E.; Ramli, R. Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film. Biosensors 2018, 8, 12.

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