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Biosensors
Volume 14
Issue 3
10.3390/bios14030146
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Review

Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications

by
Ki Sung Park
,
Tae-In Park
,
Jae Eon Lee
,
Seo-Yeong Hwang
,
Anna Choi
and
Seung Pil Pack
*
Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea
*
Author to whom correspondence should be addressed.
Biosensors 2024, 14(3), 146; https://doi.org/10.3390/bios14030146
Submission received: 31 January 2024 / Revised: 10 March 2024 / Accepted: 12 March 2024 / Published: 15 March 2024
(This article belongs to the Special Issue Organic Bioelectronic Materials and Devices for Biosensing Applications)
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Abstract

The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored the critical importance of innovative and efficient control systems for addressing future pandemics. The most effective way to control the pandemic is to rapidly suppress the spread of the virus through early detection using a rapid, accurate, and easy-to-use diagnostic platform. In biosensors that use bioprobes, the binding affinity of molecular recognition elements (MREs) is the primary factor determining the dynamic range of the sensing platform. Furthermore, the sensitivity relies mainly on bioprobe quality with sufficient functionality. This comprehensive review investigates aptamers and nanobodies recently developed as advanced MREs for SARS-CoV-2 diagnostic and therapeutic applications. These bioprobes might be integrated into organic bioelectronic materials and devices, with promising enhanced sensitivity and specificity. This review offers valuable insights into advancing biosensing technologies for infectious disease diagnosis and treatment using aptamers and nanobodies as new bioprobes.
Keywords: SARS-CoV-2; infectious disease diagnosis; biosensing technology; bioprobe; aptamer; nanobody SARS-CoV-2; infectious disease diagnosis; biosensing technology; bioprobe; aptamer; nanobody

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MDPI and ACS Style

Park, K.S.; Park, T.-I.; Lee, J.E.; Hwang, S.-Y.; Choi, A.; Pack, S.P. Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications. Biosensors 2024, 14, 146. https://doi.org/10.3390/bios14030146

AMA Style

Park KS, Park T-I, Lee JE, Hwang S-Y, Choi A, Pack SP. Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications. Biosensors. 2024; 14(3):146. https://doi.org/10.3390/bios14030146

Chicago/Turabian Style

Park, Ki Sung, Tae-In Park, Jae Eon Lee, Seo-Yeong Hwang, Anna Choi, and Seung Pil Pack. 2024. "Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications" Biosensors 14, no. 3: 146. https://doi.org/10.3390/bios14030146

APA Style

Park, K. S., Park, T.-I., Lee, J. E., Hwang, S.-Y., Choi, A., & Pack, S. P. (2024). Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications. Biosensors, 14(3), 146. https://doi.org/10.3390/bios14030146

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