Recent Advances in Electrochemiluminescence Biosensors for Mycotoxin Assay
Abstract
:1. Introduction
2. Conventional Methods for Determination of Mycotoxin
3. Sensing Strategies in Electrochemiluminescence (ECL) Biosensors for Mycotoxin Analysis
3.1. Antibody-Based Sensing
3.2. Aptamer-Based Biosensor
3.3. Molecular Imprinting
3.4. Visual ECL Analysis
4. Conclusions and Perspectives
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Sensing Mechanism | Target | Linear Range (ng/mL) | LOD (fg/mL) | Real Sample | Ref. |
---|---|---|---|---|---|
Potential-resolved | AFB1 | 5 × 10−5 to 100 | 16.44 | Walnut | [58] |
Sandwich-type ECL immunosensor | AFB1 | 1 × 10−5 to 100 | 9.55 | Corn, rice, and wheat | [67] |
Competitive immunosensor (ratiometric ECL/electrochemistry) | AFB1 | 1 × 10−5 to 100 | 5.39 | Walnut | [68] |
Self-enhanced electrochemiluminescent ratiometric immunosensor | ZEN | 1 × 10−4 to 10 | 33 | Corn hazelnut | [69] |
Peptide-based competitive immunoassays | ZEN | 1 × 10−5 to 0.1 | 3.3 | Coconut milk | [70] |
Resistance-induced ECL change | OTA | 0.01 to 100 | 5.7 × 103 | Coffee | [41] |
Resistance-induced ECL change | AFB1 | 0.05 to 100 | 1 × 104 | Lotus seed | [71] |
Competitive immunosensor | AFB1 | 0.01 to 100 | 39 × 103 | Fresh milk | [72] |
Amplification Mechanism | Target | Linear Range | LOD (fg/mL) | Real Sample | Ref. |
---|---|---|---|---|---|
RCA | OTA | 0.075 to 10 pg/mL | 8 fg/mL | Red wine | [74] |
HCR | OTA | 0.01 ng/mL to 5 ng/mL; 5 ng/mL to 100 ng/mL | 3 pg/mL | Rice, wheat, corn, sorghum, barley, buckwheat | [78] |
HCR and Dual-signal amplification strategy | OTA | 12.40 pM to 6.19 nM | 5.6 pM | Corn | [77] |
DNA walker | AFB1 | 1.0 fg/mL to 10 ng/mL | 0.58 fg/mL | Corn, peanut | [79] |
DNA walker | OTA | 10 fg/mL to 100 ng/mL | 3.19 fg/mL | Corn oil, rapeseed oil, sesame oil | [80] |
Loop-mediated isothermal amplification | OTA | 0.00005 nM to 100 nM | 10 fM | Red wine | [75] |
ECL energy transfer | AFB1 | 5.0 pM to 10 nM | 0.12 pM | Peanut, maize, wheat | [81] |
ECL energy transfer | OTA | 0.0005 to 50 ng/mL | 0.17 pg/mL | Corn | [82] |
Dual-signal amplification strategy | ZEN | 0.001 to 200 μg/kg | 9.75 × 10−5 μg/kg | Maize | [62] |
Dual-quenching effects | ZEN | 1.0 × 10−6 to 50 ng/mL | 0.85 fg/mL | Maize | [83] |
Dual signal amplification of GQDs and AuNRs | AFB1 | 0.01 to 100 ng/mL | 3.75 pg/mL | Peanut, maize, wheat | [84] |
Exonuclease-assisted target recycling amplification | OTA | 0.01 to 1.0 ng/mL | 2 pg/mL | Corn | [85] |
Horseradish peroxidase | AFB1 | 0.1 to 100 ng/mL | 0.033 ng/mL | Rice, wheat, corn, sorghum, barley, buckwheat | [86] |
Self-enhanced NPs (NGQDs- Ru@SiO2) | ZEN | 10 fg/mL to 10 ng/mL | 1 fg/ mL | Corn flour | [87] |
Apt-GMNPs-GO-L-AgNPs | AFM1 | 10 to 200 ng/mL | 0.05 ng/mL | Milk | [88] |
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Jin, L.; Liu, W.; Xiao, Z.; Yang, H.; Yu, H.; Dong, C.; Wu, M. Recent Advances in Electrochemiluminescence Biosensors for Mycotoxin Assay. Biosensors 2023, 13, 653. https://doi.org/10.3390/bios13060653
Jin L, Liu W, Xiao Z, Yang H, Yu H, Dong C, Wu M. Recent Advances in Electrochemiluminescence Biosensors for Mycotoxin Assay. Biosensors. 2023; 13(6):653. https://doi.org/10.3390/bios13060653
Chicago/Turabian StyleJin, Longsheng, Weishuai Liu, Ziying Xiao, Haijian Yang, Huihui Yu, Changxun Dong, and Meisheng Wu. 2023. "Recent Advances in Electrochemiluminescence Biosensors for Mycotoxin Assay" Biosensors 13, no. 6: 653. https://doi.org/10.3390/bios13060653