Development of a Self-Viscosity and Temperature-Compensated Technique for Highly Stable and Highly Sensitive Bead-Based Diffusometry
Abstract
:1. Introduction
2. Materials and Methods
2.1. Derivation of Self-Compensated Particle Diameter
2.1.1. Particle Tracking for Trajectory
2.1.2. Time-Dependent Blinking Signal
2.2. Experimental Setup
2.3. Preparations of Functionalized Janus Particles
2.3.1. Fabrication of Janus Particles
2.3.2. Sandwiched Immunocomplexed Janus Particles
2.4. Generation of Simulated Images
3. Results and Discussion
3.1. Determination of Particle Diameter out of Rotational Diffusivity and Translational Diffusivity
3.2. Evaluations of Simulated Bead-Based Brownian Motion with Viscosity and Temperature Changes
3.3. Evaluations of Experimental Viscosity and Temperature Changes
3.4. Realization of Highly Stable and Sensitive Immunosensing
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Parameter | Value | Parameter | Value | Parameter | Value |
---|---|---|---|---|---|
Pixel Size | 3.45 µm | Magnification | 40× | Temperature | 25 °C |
Frame Rate | 50 Hz | NA † | 0.6 | Viscosity | 1 mPa·s |
Ex * | 630 nm | Elapsed Time | 10 s | dp ‡ | 1 μm |
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Chen, W.-L.; Chuang, H.-S. Development of a Self-Viscosity and Temperature-Compensated Technique for Highly Stable and Highly Sensitive Bead-Based Diffusometry. Biosensors 2022, 12, 362. https://doi.org/10.3390/bios12060362
Chen W-L, Chuang H-S. Development of a Self-Viscosity and Temperature-Compensated Technique for Highly Stable and Highly Sensitive Bead-Based Diffusometry. Biosensors. 2022; 12(6):362. https://doi.org/10.3390/bios12060362
Chicago/Turabian StyleChen, Wei-Long, and Han-Sheng Chuang. 2022. "Development of a Self-Viscosity and Temperature-Compensated Technique for Highly Stable and Highly Sensitive Bead-Based Diffusometry" Biosensors 12, no. 6: 362. https://doi.org/10.3390/bios12060362