Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases
Abstract
:1. Introduction
2. NIR-II Fluorescent Probes
2.1. Organic NIR-II Fluorescent Probes
2.2. Inorganic NIR-II Fluorophores
3. Activatable NIR-II Fluorescent Probes
3.1. pH
3.2. Enzymes
3.3. ROS
3.4. RNS
3.5. RSS
3.6. Hypoxia
3.7. Viscosity
3.8. Dual-Responsive
4. Summary and Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Activation Mode | Probe Name | Probe Fluorophores | Activation Mechanism | Excitation/ Emission (nm) | Biological Model | Refs |
---|---|---|---|---|---|---|
pH | BTC1070 | Pentamethine cyanine | Protonation, inhibition of ICT effect | 808/1000–1300 | Simulated gastric fluid with different pH | [54] |
pH | Ag2S Ve | Ag2S | Protonation, increased hydrophilicity | 808/1250 | 4T1 breast cancer | [63] |
β-Gal | BOD-M-βGal | BODPY derivatives | Hydrolyzation of β-galactose residues | 808/900–1300 | SKOV3 ovarian cancer | [72] |
MMP14 | A&MMP@Ag2S-AF7P | Ag2S | Consumption of NIR absorber A1094 | 785/1050 | NB | [77] |
H2O2 | Ag/Ag2S JNP | Ag2S | Oxidizing the plasmonic Ag parts | 825/1250 | MCF-7 breast cancer | [82] |
·OH | Hydro-1080 | cyanine dyes | Conjugated system recovery | 980/1100 | Liver injury | [88] |
HClO | SPNPs | Degradation of the receptor ITTC | 808/1010 | Inflamed paws | [95] | |
ONOO− | V&A@Ag2S | Ag2S | Consumption of A1094 chromophore | 825/1050 | TBI | [105] |
ONOO− | V&C/PbS@Ag2Se | PbS@Ag2Se | Consumption of absorber Cy7.5 | 808/1616 | Ischemic stroke | [109] |
NO | AOSNP | Ag2S | Energy receptor units are converted | 808/900–1150 | Liver injury | [115] |
H2S | WH-3 | BODIPY derivatives | Release fluorescence quencher | 980/1140 | HCT-116 colon cancer | [121] |
Hypoxia (NTR) | IR-1048-MZ | IR-1048 | MZ group was reduced | 980/1046 | A549 lung cancer | [126] |
Viscosity | WD-NO2 | BODIPY derivatives | Intramolecular rotation of chemical bonds is limited | 808/900–1400 | Abnormal liver viscosity | [131] |
Hyal and GSH | HISSNPs | IR-1061 | Fracture of HA chains and disulfide bonds | 808/1070 | MCF-7 breast cancer | [139] |
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Li, D.; Pan, J.; Xu, S.; Fu, S.; Chu, C.; Liu, G. Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases. Biosensors 2021, 11, 436. https://doi.org/10.3390/bios11110436
Li D, Pan J, Xu S, Fu S, Chu C, Liu G. Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases. Biosensors. 2021; 11(11):436. https://doi.org/10.3390/bios11110436
Chicago/Turabian StyleLi, Dong, Jie Pan, Shuyu Xu, Shiying Fu, Chengchao Chu, and Gang Liu. 2021. "Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases" Biosensors 11, no. 11: 436. https://doi.org/10.3390/bios11110436