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Comment published on 1 March 2022, see Biosensors 2022, 12(3), 152.
Brief Report

Performance of the Intermittently Scanned Continuous Glucose Monitoring (isCGM) System during a High Oral Glucose Challenge in Adults with Type 1 Diabetes—A Prospective Secondary Outcome Analysis

1
Cardiovascular Diabetology Research Group, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
2
Division of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95445 Bayreuth, Germany
3
Center for Biomarker Research in Medicine (CBMed), 8010 Graz, Austria
4
Exercise Physiology, Training & Training Therapy Research Group, Institute of Sports Science, University of Graz, 8010 Graz, Austria
5
Zayed Center for Health Sciences (ZCHS), United Arab Emirates University, Al Ain 15551, UAE
*
Author to whom correspondence should be addressed.
Biosensors 2021, 11(1), 22; https://doi.org/10.3390/bios11010022
Received: 9 December 2020 / Revised: 5 January 2021 / Accepted: 14 January 2021 / Published: 15 January 2021
(This article belongs to the Section Biosensors and Healthcare)
To assess intermittently scanned continuous glucose monitoring (isCGM) performance for different rates of change in plasma glucose (RCPG) during glycemic challenges in type 1 diabetes (T1D). Nineteen people with T1D (7 females; age 35 ± 11 years; HbA1c 7.3 ± 0.6% (56 ± 7 mmol/mol)) performing two glycemic challenges (OGTT) were included. During OGTTs, plasma glucose was compared against sensor glucose for timepoints 0 min (pre-OGTT), +15 min, +30 min, +60 min, +120 min, +180 min, and +240 min by means of median absolute (relative) difference (MARD and MAD) and Clarke Error Grid (CEG), then was stratified for RCPG and glycemic ranges. Overall, MARD was 8.3% (4.0–14.8) during hypoglycemia level 1 18.8% (15.8–22.0), euglycemia 9.5% (4.3–15.1), hyperglycemia level 1 9.4% (4.0–17.2), and hyperglycemia level 2 7.1% (3.3–11.9). The MARD was associated with the RCPG (p < 0.0001), detailing significant differences in comparison of low, moderate, high, and very high RCPG (p = 0.014). Overall, CEG resulted in 88% (212 values) of comparison points in zone A, 12% (29 values) in zone B, and 0.4% (1 value) in zone D. The isCGM system was accurate during OGTTs. Its performance was dependent on the RCPG and showed an overestimation of the actual reference glucose during hypoglycemia. View Full-Text
Keywords: isCGM; glycemia; accuracy isCGM; glycemia; accuracy
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MDPI and ACS Style

Moser, O.; Tripolt, N.; Pferschy, P.; Obermayer, A.; Kojzar, H.; Mueller, A.; Yildirim, H.; Sourij, C.; Eckstein, M.; Sourij, H. Performance of the Intermittently Scanned Continuous Glucose Monitoring (isCGM) System during a High Oral Glucose Challenge in Adults with Type 1 Diabetes—A Prospective Secondary Outcome Analysis. Biosensors 2021, 11, 22. https://doi.org/10.3390/bios11010022

AMA Style

Moser O, Tripolt N, Pferschy P, Obermayer A, Kojzar H, Mueller A, Yildirim H, Sourij C, Eckstein M, Sourij H. Performance of the Intermittently Scanned Continuous Glucose Monitoring (isCGM) System during a High Oral Glucose Challenge in Adults with Type 1 Diabetes—A Prospective Secondary Outcome Analysis. Biosensors. 2021; 11(1):22. https://doi.org/10.3390/bios11010022

Chicago/Turabian Style

Moser, Othmar, Norbert Tripolt, Peter Pferschy, Anna Obermayer, Harald Kojzar, Alexander Mueller, Hakan Yildirim, Caren Sourij, Max Eckstein, and Harald Sourij. 2021. "Performance of the Intermittently Scanned Continuous Glucose Monitoring (isCGM) System during a High Oral Glucose Challenge in Adults with Type 1 Diabetes—A Prospective Secondary Outcome Analysis" Biosensors 11, no. 1: 22. https://doi.org/10.3390/bios11010022

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