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Open AccessArticle

Surface Probe Linker with Tandem Anti-Fouling Properties for Application in Biosensor Technology

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Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F1, 842 48 Bratislava, Slovakia
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Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S, Canada
*
Author to whom correspondence should be addressed.
Biosensors 2020, 10(3), 20; https://doi.org/10.3390/bios10030020
Received: 22 January 2020 / Revised: 18 February 2020 / Accepted: 26 February 2020 / Published: 3 March 2020
This paper describes the anti-fouling capability of the novel monolayer-forming surface linker 3-(3-(trichlorosilylpropyloxy) propanoyl chloride (MEG-Cl). This compound was successfully attached to quartz crystal surfaces which are employed in an electromagnetic piezoelectric acoustic sensor (EMPAS) configuration. The MEG-Cl coated surface was both employed with Ni-NTA for the binding of recombinant proteins and for the tandem property of the avoidance of fouling from serum and milk. The MEG-Cl coated surfaces were found to provide a large degree of anti-fouling on the EMPAS device, and were comparable to previously studied MEG-OH surfaces. Importantly, the monolayer continued to provide anti-fouling capability to the biosensor following extension with Ni-NTA in place. Accordingly, this surface linker provides an attractive system for use in biosensor technology in terms of both its anti-fouling and linking properties. View Full-Text
Keywords: anti-fouling monolayer; electromagnetic piezoelectric acoustic sensor; blood serum; milk anti-fouling monolayer; electromagnetic piezoelectric acoustic sensor; blood serum; milk
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MDPI and ACS Style

Spagnolo, S.; De La Franier, B.; Hianik, T.; Thompson, M. Surface Probe Linker with Tandem Anti-Fouling Properties for Application in Biosensor Technology. Biosensors 2020, 10, 20.

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