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Open AccessArticle

Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles

1
School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Hai Quan Road, Shanghai 201418, China
2
Department of Dairy and Food Science, South Dakota State University, Brookings, SD 57007, USA
3
Biological Engineering and Whistler Carbohydrate Research Center, Philip E. Nelson Hall of Food Science, Room 2195745 Agricultural Mall, Purdue University, West Lafayette, IN 47906, USA
4
Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, OH 43210-1007, USA
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(8), 1073; https://doi.org/10.3390/nano9081073
Received: 3 July 2019 / Revised: 15 July 2019 / Accepted: 22 July 2019 / Published: 26 July 2019
Curcumin displays anti-cancer, anti-inflammatory and anti-obesity properties but its water insolubility limits the wholesome utility. In this study, curcumin has been encapsulated in an amphiphilic biopolymer to enhance its water solubility. This was accomplished through self-assembly of octenyl succinic anhydride–short glucan chains (OSA–SGC) and curcumin. The nanoparticles were prepared with the degree of substitution (DS) of 0.112, 0.286 and 0.342 of OSA. Thus prepared nanoparticles were in the range of 150–200 nm and display high encapsulation efficiency and high loading capacity of curcumin. The Fourier-transform infrared (FTIR) and X-ray diffraction analyses confirmed the curcumin loading in the OSA–SGC nanoparticles. The complexes possessed a V-type starch structure. The thermo gravimetric analysis (TGA) revealed the thermal stability of encapsulated curcumin. The OSA–SGC nanoparticles greatly improved the curcumin release and dissolution, and in-turn promoted the sustained release. View Full-Text
Keywords: curcumin; short glucan chains; octenyl succinic anhydride; amphiphilic biopolymer; in vitro digestion curcumin; short glucan chains; octenyl succinic anhydride; amphiphilic biopolymer; in vitro digestion
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MDPI and ACS Style

Hu, Z.; Feng, T.; Zeng, X.; Janaswamy, S.; Wang, H.; Campanella, O. Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles. Nanomaterials 2019, 9, 1073. https://doi.org/10.3390/nano9081073

AMA Style

Hu Z, Feng T, Zeng X, Janaswamy S, Wang H, Campanella O. Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles. Nanomaterials. 2019; 9(8):1073. https://doi.org/10.3390/nano9081073

Chicago/Turabian Style

Hu, Zhongshan; Feng, Tao; Zeng, Xiaolan; Janaswamy, Srinivas; Wang, Hui; Campanella, Osvaldo. 2019. "Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles" Nanomaterials 9, no. 8: 1073. https://doi.org/10.3390/nano9081073

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