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Acetic-Acid Plasma-Polymerization on Polymeric Substrates for Biomedical Application

Institute of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan
Bachelor Program for Design and Materials for Medical Equipment and Devices, Da Yeh University, Changhua 515, Taiwan
Department of Materials Engineering, Tatung University, Taipei 104, Taiwan
Department of Raw Materials and Yarns, Taiwan Textile Research Institute, New Taipei City 236, Taiwan
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(7), 941;
Received: 27 May 2019 / Revised: 22 June 2019 / Accepted: 24 June 2019 / Published: 28 June 2019
PDF [3994 KB, uploaded 2 July 2019]
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Cold plasma is an emerging technology offering many potential applications for regenerative medicine or tissue engineering. This study focused on the characterization of the carboxylic acid functional groups deposited on polymeric substrates using a plasma polymerization process with an acetic acid precursor. The acetic acid precursor contains oxygen and hydrocarbon that, when introduced to a plasma state, forms the polylactide-like film on the substrates. In this study, polymeric substrates were modified by depositing acetic acid plasma film on the surface to improve hydrophilic quality and biocompatibility. The experimental results that of electron spectroscopy for chemical analysis (ESCA) to show for acetic acid film, three peaks corresponding to the C–C group (285.0 eV), C–O group (286.6 eV), and C=O group (288.7 eV) were observed. The resulting of those indicated that appropriate acetic acid plasma treatment could increase the polar components on the surface of substrates to improve the hydrophilicity. In addition, in vitro cell culture studies showed that the embryonic stem (ES) cell adhesion on the acetic acid plasma-treated polymeric substrates is better than the untreated. Such acetic acid film performance makes it become a promising candidate as the surface coating layer on polymeric substrates for biomedical application. View Full-Text
Keywords: acetic acid; plasma polymerization; hydrophilic; surface modification acetic acid; plasma polymerization; hydrophilic; surface modification

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Liao, S.-C.; Chen, K.-S.; Chien, J.-L.; Chen, S.-C.; Lin, W.-L. Acetic-Acid Plasma-Polymerization on Polymeric Substrates for Biomedical Application. Nanomaterials 2019, 9, 941.

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