Facile Synthesis of MnO2 Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents
2.2. Materials Characterization
2.3. Synthsis of MnO2NFs/NNrGO Comoposites
2.4. Fabrication of MnO2NFs/NrGO Modified Electrodes
2.5. Procedures for Electrochemical Mesurements
3. Results and Discussion
3.1. Physical Chararazation
3.2. Evaluation of Electrochemical Performances
3.3. Voltammetric Responses of DA and UA at Various Electrodes
3.4. Optimization of Voltammetrical Parameters
3.4.1. Effect of pH
3.4.2. Effect of Scanning Rate
3.4.3. Influence of Accumulation Parameters
3.5. Individual and Simultaneous Determination of DA and UA
3.6. Selectivity, Repeatability, and Reproducbility Assay
3.7. Determination of DA and UA in Human Serum Samples
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Electrodes | Methods | Detection Range (μM) | LOD (μM) | Ref. | ||
---|---|---|---|---|---|---|
DA | UA | DA | UA | |||
Au/Cu2O/rGO/GCE | a DPV | 10–90 | 100–900 | 3.9 | 6.5 | [7] |
NrGO/GCE | DPV | 0.5–170 | 0.1–20 | 0.25 | 0.045 | [46] |
Pd/RGO/GCE | DPV | 0.45–71 | 6–469.5 | 0.18 | 1.6 | [47] |
Pt/RGO/GCE | DPV | 10–170 | 10–130 | 0.25 | 0.45 | [48] |
ZnO/SPCE | DPV | 0.1–374 | 0.1–169 | 0.004 | 0.00849 | [49] |
PtNi@MoS2/GCE | DPV | 0.5–150 | 0.5–600 | 0.1 | 0.1 | [50] |
Au–Pt/GO–ERGO | DPV | 0.0682–49,800 | 0.125–82,800 | 0.0207 | 0.0407 | [51] |
HFP/GCE | DPV | 1–200 | 20–400 | 0.016 | 0.218 | [52] |
MoS2/GCE | DPV | 1–900 | 1–60 | 0.15 | 0.06 | [53] |
ZnO/PANI/rGO/GCE | DPV | 0.1–90 | 0.5–90 | 0.017 | 0.12 | [54] |
MoS2/rGO/GCE | DPV | 5–545 | 25–2745 | 0.05 | 0.46 | [55] |
NCNF/GCE | DPV | 1–10; 10–200 | 5–200 | 0.5 | 1 | [56] |
PTPCNs/GCE | DPV | 1–100 | 5–200 | 0.078 | 0.17 | [57] |
MnO2NFs/NrGO/GCE | LSV | 0.2–6.0; 6.0–100 | 0.2–6.0; 6.0–100 | 0.036 | 0.029 | This work |
a Samples | Detected (μM) | Added (μM) | Found (μM) | RSD (%) | Recovery (%) | |
---|---|---|---|---|---|---|
Serum | DA | b ND | 20 | 18.98 | 4.25 | 94.9 |
40 | 38.48 | 3.76 | 96.2 | |||
UA | 21.8 | 20 | 42.92 | 2.98 | 105.6 | |
40 | 63.74 | 2.45 | 104.9 |
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Wan, X.; Yang, S.; Cai, Z.; He, Q.; Ye, Y.; Xia, Y.; Li, G.; Liu, J. Facile Synthesis of MnO2 Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid. Nanomaterials 2019, 9, 847. https://doi.org/10.3390/nano9060847
Wan X, Yang S, Cai Z, He Q, Ye Y, Xia Y, Li G, Liu J. Facile Synthesis of MnO2 Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid. Nanomaterials. 2019; 9(6):847. https://doi.org/10.3390/nano9060847
Chicago/Turabian StyleWan, Xuan, Shihui Yang, Zhaotian Cai, Quanguo He, Yabing Ye, Yonghui Xia, Guangli Li, and Jun Liu. 2019. "Facile Synthesis of MnO2 Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid" Nanomaterials 9, no. 6: 847. https://doi.org/10.3390/nano9060847