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Facile Synthesis of MnO2 Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid

1
College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China
2
Zhuzhou Institute for Food and Drug Control, Zhuzhou 412000, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(6), 847; https://doi.org/10.3390/nano9060847
Received: 13 May 2019 / Revised: 28 May 2019 / Accepted: 28 May 2019 / Published: 2 June 2019
(This article belongs to the Special Issue Carbon-Based Nanomaterials for (Bio)Sensors Development)
This study reports facile synthesis of MnO2 nanoflowers/N-doped reduced graphene oxide (MnO2NFs/NrGO) composite and its application on the simultaneous determination of dopamine (DA) and uric acid (UA). The microstructures, morphologies, and electrochemical performances of MnO2NFs/NrGO were studied using X-ray diffraction (XRD), scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS), respectively. The electrochemical experiments showed that the MnO2NFs/NrGO composites have the largest effective electroactive area and lowest charge transfer resistance. MnO2NFs/NrGO nanocomposites displayed superior catalytic capacity toward the electro-oxidation of DA and UA due to the synergistic effect from MnO2NFs and NrGO. The anodic peak currents of DA and UA increase linearly with their concentrations varying from 0.2 μM to 6.0 μM. However, the anodic peak currents of DA and UA are highly correlated to the Napierian logarithm of their concentrations ranging from 6.0 μM to 100 μM. The detection limits are 0.036 μM and 0.029 μM for DA and UA, respectively. Furthermore, the DA and UA levels of human serum samples were accurately detected by the proposed sensor. Combining with prominent advantages such as facile preparation, good sensitivity, and high selectivity, the proposed MnO2NFs/NrGO nanocomposites have become the most promising candidates for the simultaneous determination of DA and UA from various actual samples. View Full-Text
Keywords: dopamine; uric acid; MnO2 nanoflowers; N-doped reduced graphene oxide; voltammetric sensor dopamine; uric acid; MnO2 nanoflowers; N-doped reduced graphene oxide; voltammetric sensor
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MDPI and ACS Style

Wan, X.; Yang, S.; Cai, Z.; He, Q.; Ye, Y.; Xia, Y.; Li, G.; Liu, J. Facile Synthesis of MnO2 Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid. Nanomaterials 2019, 9, 847.

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