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Channeled ECM-Based Nanofibrous Hydrogel for Engineering Vascularized Cardiac Tissues

1
School for Molecular Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel
2
Department of Materials Science and Engineering, Tel Aviv University, Tel Aviv 69978, Israel
3
The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel
4
Sagol Center for Regenerative Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel
*
Author to whom correspondence should be addressed.
Those authors contributed equally to this work.
Nanomaterials 2019, 9(5), 689; https://doi.org/10.3390/nano9050689
Received: 18 March 2019 / Revised: 22 April 2019 / Accepted: 26 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Nanoscale Materials and Technologies in Tissue Engineering)
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Abstract

Hydrogels are widely used materials for cardiac tissue engineering. However, once the cells are encapsulated within hydrogels, mass transfer to the core of the engineered tissue is limited, and cell viability is compromised. Here, we report on the development of a channeled ECM-based nanofibrous hydrogel for engineering vascularized cardiac tissues. An omentum hydrogel was mixed with cardiac cells, patterned to create channels and closed, and then seeded with endothelial cells to form open cellular lumens. A mathematical model was used to evaluate the necessity of the channels for maintaining cell viability and the true potential of the vascularized hydrogel to form a viable cardiac patch was studied. View Full-Text
Keywords: ECM-based hydrogels; cardiac tissue engineering; vascularization ECM-based hydrogels; cardiac tissue engineering; vascularization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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MDPI and ACS Style

Arvatz, S.; Wertheim, L.; Fleischer, S.; Shapira, A.; Dvir, T. Channeled ECM-Based Nanofibrous Hydrogel for Engineering Vascularized Cardiac Tissues. Nanomaterials 2019, 9, 689.

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